Evidence map›Paper›PMID 25898804›Full record

ArticleJournal of psychiatric research2015

Assessment of Lifespan Functioning Attainment (ALFA) scale: A quantitative interview for self-reported current and functional decline in schizophrenia.

Jamie Joseph, William S Kremen, Stephen J Glatt, Carol E Franz, Sharon D Chandler, Xiaohua Liu, Barbara K Johnson, Ming T Tsuang, Elizabeth W Twamley

Abstract read
In one paragraph

Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jamie JosephCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA.
William S KremenCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive (116A), San Diego, CA 92161, USA.
Stephen J GlattPsychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams Street, 3710 Neuroscience Research Building, Institute for Human Performance, Syracuse, NY 13210, USA.
Carol E FranzCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA.
Sharon D ChandlerCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA.
Xiaohua LiuCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA.
Barbara K JohnsonCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA.
Ming T TsuangCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive (116A), San Diego, CA 92161, USA.
Elizabeth W TwamleyCenter for Behavior Genomics, Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive #0603, La Jolla, CA 92093-0603, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive (116A), San Diego, CA 92161, USA. Electronic address: etwamley@ucsd.edu.

Funding

The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
Genetic Predictors of Neuropsychological and Functional Outcomes in SchizophreniaR01MH081861 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TSUANG, MING T. · 2008 to 2013
$2.7M
2/2-Expanding Rapid Ascertainment Networks Of Schizophrenia Families In TaiwanR01MH085521 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI GLATT, STEPHEN J · 2008 to 2012
$1.5M
Cognitive Training to Improve Work Outcomes in Severe Mental IllnessR01MH080150 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TWAMLEY, ELIZABETH W · 2008 to 2012
$1.4M
NIA NIH HHS R01 AG018386NIA NIH HHS R01AG018386NIMH NIH HHS R01 MH080150NIMH NIH HHS R01MH080150NIMH NIH HHS R01 MH081861NIMH NIH HHS R01MH081861NIMH NIH HHS R01 MH085521NIMH NIH HHS R01MH085521
6 · The paper itself

Abstract

Schizophrenia has been characterized as a disorder with poor outcomes across various functional domains, especially social and occupational functioning. Although these outcomes have been investigated based on patients' current functioning, few studies have considered the assessment of functional outcomes across the lifespan in schizophrenia. We developed a novel and brief scale of adulthood lifespan functioning, the Assessment of Lifespan Functioning Attainment (ALFA). We assessed current functioning and percentage of pre- and post-psychosis onset engagement for five functional domains including paid employment, living independently, romantic partnerships, close friendships, and recreational engagement with others. Pre-to post-psychosis functional decline was observed for all domains, with paid employment having the greatest decline (d = 2.68) and living independently having the least decline (d = .59). Our exploratory factor analysis suggests that a single factor accounted for the most variance in Pre-Psychosis Functioning in ALFA domains. Two factors explain the majority of variance in Post-Psychosis Functioning and Pre-to-Post Psychosis Decline: a sociability factor (close friendships and recreational engagement with others) and an independence factor (paid employment, living independently, romantic relationships). To our knowledge, this is the first study to report on a self-reported quantitative assessment of adult lifespan functioning in schizophrenia. The ALFA scale may be a useful tool for future research on functional outcomes in schizophrenia.

Indexed as

Schizophrenic PsychologySelf ReportAdultCognition DisordersEmploymentFemaleHumansIndependent LivingInterpersonal RelationsMaleMiddle AgedNeuropsychological TestsPsychotic DisordersQuality of LifeSchizophreniaStatistics as TopicEmploymentFunctional outcomePsychosisSocial functioning

Identifiers

PMID25898804
PMCPMC4439273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.