ReviewJournal of investigational allergology & clinical immunology2015
Group 2 innate lymphoid cells: new players in human allergic diseases.
Review in Journal of investigational allergology & clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Central compartment atopic disease: Advances in pathogenesis and stratified treatment.The Journal of international medical research · 2026Review
- Article
- Staphylococcus aureus exacerbates dermal IL-33/ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin.JCI insight · 2024Article
- The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies.Journal of inflammation research · 2024Review
- Chronic Rhinosinusitis,Biomedicines · 2022Review
- Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation.Mucosal immunology · 2022Article
- PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.BMC immunology · 2021Article
- Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s.Scientific reports · 2021Article
- Role of ILC2 in Viral-Induced Lung Pathogenesis.Frontiers in immunology · 2021Review
- Asthma biologics: Comparing trial designs, patient cohorts and study results.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
- Improved Anti-Inflammatory Effects of Liposomal Astaxanthin on a Phthalic Anhydride-Induced Atopic Dermatitis Model.Frontiers in immunology · 2020Article
- Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management.Journal of clinical medicine · 2019Review
- Quantum dots and mouse strain influence house dust mite-induced allergic airway disease.Toxicology and applied pharmacology · 2019Article
- Group 2 Innate Lymphoid Cells Participate in Renal Fibrosis in Diabetic Kidney Disease Partly via TGF-Journal of diabetes research · 2019Article
- Airway innate lymphoid cells in the induction and regulation of allergy.Allergology international : official journal of the Japanese Society of Allergology · 2019Review
- Decreased CRTH2 Expression and Response to Allergen Re-stimulation on Innate Lymphoid Cells in Patients With Allergen-Specific Immunotherapy.Allergy, asthma & immunology research · 2018Article
- A Major Population of Functional KLRG1ImmunoHorizons · 2018Article
- Role of innate lymphoid cells in obesity and metabolic disease (Review).Molecular medicine reports · 2018Review
- βThe Journal of allergy and clinical immunology · 2018Article
- Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis.American journal of rhinology & allergy · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Allergic diseases are characterized by tissue eosinophilia, mucus secretion, IgE production, and activation of mast cells and TH2 cells. Production of TH2 cytokines including IL-4, IL-5, IL-9, and IL-13 has mainly been attributed to CD4+T(H)2 cells. However, the recent discovery of group 2 innate lymphoid cells (ILC2s) in humans and findings from experimental disease models have challenged conventional concepts associated with the contribution of specific cells to type 2 inflammation in allergic diseases. ILC2s produce high levels of T(H)2 cytokines and have been detected in human lung tissue, peripheral blood, the gastrointestinal tract, skin, and sinonasal tissue, suggesting that ILC2s could contribute to chronic rhinosinusitis, asthma, atopic dermatitis, and gastrointestinal allergic disease. Moreover, depletion of ILC2s in animal models suggests a role for these cells in atopic dermatitis and asthma. This review will focus on the role of ILC2s in human allergy and asthma and provide a mechanistic insight from animal models.
Indexed as
Identifiers
25898689PMC4545833W2188513396What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.