Evidence map›Paper›PMID 25898416›Full record

ArticleMolecules (Basel, Switzerland)2015

Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L.

Javad Sharifi-Rad, Seyedeh Mahsan Hoseini-Alfatemi, Majid Sharifi-Rad, Mehdi Sharifi-Rad, Marcello Iriti, Marzieh Sharifi-Rad, Razieh Sharifi-Rad, Sara Raeisi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Current pharmaceutical design · 2025
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  4. Article
  5. The Volatile Organic Compounds ofMicroorganisms · 2023
    Article
  6. An Inventory of Anthelmintic Plants across the Globe.Pathogens (Basel, Switzerland) · 2023
    Review
  7. Inferring Therapeutic Targets inLife (Basel, Switzerland) · 2022
    Article
  8. Biologically Active Constituents from Plants of the Genus Xanthium.Progress in the chemistry of organic natural products · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Javad Sharifi-RadZabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran. javad.sharifirad@gmail.com.
Seyedeh Mahsan Hoseini-AlfatemiPediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran 15468-15514, Iran. m.hoseinialfatemi@gmail.com.
Majid Sharifi-RadDepartment of Range and Watershed Management, Faculty of Natural Resources, University of Zabol, Zabol 98615-538, Iran. majid.sharifirad@gmail.com.
Mehdi Sharifi-RadZabol University of Medical Sciences, Zabol 61663335, Iran. mehdi_sharifirad@yahoo.com.
Marcello IritiDepartment of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy. marcello.iriti@unimi.it.
Marzieh Sharifi-RadDepartment of Chemistry, Faculty of Science, University of Zabol, Zabol 98615-538, Iran. marzieh.sharifirad@gmail.com.
Razieh Sharifi-RadDepartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan 33431063, Iran. razieh.sharifirad@gmail.com.
Sara RaeisiDepartment of Fishery, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan 49138-15739, Iran. sarah.raeisi69@gmail.com.
Zabol University · IRGorgan University of Agricultural Sciences and Natural Resources · IRShahid Beheshti University of Medical Sciences · IRUniversity of Milan · ITUniversity of Sistan and Baluchestan · IRZabol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemical composition of the essential oil (EO) from fresh cocklebur (Xanthium strumarium L.) leaves was investigated by GC-MS. The antimicrobial activity of the EO was tested against Gram-positive and Gram-negative bacteria and fungi. Scolicidal activity was assayed against Echinococcus granulosus protoscolices. In total, 34 compounds were identified, accounting for 98.96% of the EO. The main compounds in the EO were cis-β-guaiene (34.2%), limonene (20.3%), borneol (11.6%), bornyl acetate (4.5%), β-cubebene (3.8%), sabinene (3.6%), phytol (3.1%), β-selinene (2.8%), camphene (2.2%), α-cubebene (2.4%), β-caryophyllene (1.9%), α-pinene (1.8%) and xanthinin (1.04%). The antibacterial and antifungal screening of the EO showed that all assayed concentrations significantly inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger (MIC = 0.5 ± 0.1, 1.3 ± 0.0, 4.8 ± 0.0, 20.5 ± 0.3, 55.2 ± 0.0 and 34.3 ± 0.0 µg/mL, respectively). The scolicidal assay indicated that the EO exhibited a significant activity against E. granulosus protoscolices. To the best of our knowledge, this is the first report on the scolicidal activity of X. strumarium. Because of the emergence of antimicrobial drug resistance, the study of new effective natural chemotherapeutic agents, such as the X. strumarium EO, possibly with low side effects, represents a very promising approach in biomedical research.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsOils, VolatilePhytochemicalsPlant ExtractsPlant LeavesXanthiumAnti-Bacterial AgentsAntifungal AgentsOils, VolatilePhytochemicalsPlant Extracts

Identifiers

PMID25898416
PMCPMC6272595
OpenAlexW1994243931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.