ReviewMolecules (Basel, Switzerland)2015
Perinatal asphyxia: a review from a metabolomics perspective.
Review in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence of neonatal asphyxia and associated risk factors: a systematic review and cumulative meta-analysis.BMC pediatrics · 2025Pooled it
- Article
- Study of Ovarian Damage in Piglets in an Experimental Model of Neonatal Asphyxia.Children (Basel, Switzerland) · 2025Article
- Article
- Development and Characterization of Interstitial-Fluid-Mimicking Solutions for Pre-Clinical Assessment of Hypoxia.Diagnostics (Basel, Switzerland) · 2023Article
- Birth asphyxia and its associated factors among newborns at a tertiary hospital: evidence from Southern Ethiopia.African health sciences · 2023Article
- Review
- Childhood Obesity and the Cryptic Language of the Microbiota: Metabolomics' Upgrading.Metabolites · 2023Review
- Comparison of new biomarkers in the diagnosis of perinatal asphyxia.Iranian journal of child neurology · 2023Article
- Machine learning models based on clinical indices and cardiotocographic features for discriminating asphyxia fetuses-Porto retrospective intrapartum study.Frontiers in public health · 2023Article
- Resuscitation of Term Compromised and Asphyctic Newborns: Better with Intact Umbilical Cord?Geburtshilfe und Frauenheilkunde · 2022Article
- Risk Factors of Birth Asphyxia among Newborns at Debre Markos Comprehensive Specialized Referral Hospital, Northwest Ethiopia: Unmatched Case-Control Study.Ethiopian journal of health sciences · 2022Article
- Pathophysiology of Perinatal Asphyxia in Humans and Animal Models.Biomedicines · 2022Review
- Microbial Translocation and Perinatal Asphyxia/Hypoxia: A Systematic Review.Diagnostics (Basel, Switzerland) · 2022Review
- Mitochondrial dysfunction in perinatal asphyxia: role in pathogenesis and potential therapeutic interventions.Molecular and cellular biochemistry · 2021Review
- Neuroprotective strategies of cerebrolysin for the treatment of infants with neonatal hypoxic-ischemic encephalopathy.Acta neurologica Belgica · 2021Review
- Article
- A Metabolomic Approach in Search of Neurobiomarkers of Perinatal Asphyxia: A Review of the Current Literature.Frontiers in pediatrics · 2021Review
- A new microdialysis probe for continuous lactate measurement during fetal monitoring: Proof of concept in an animal model.Acta obstetricia et gynecologica Scandinavica · 2020Article
- Statistical differences resulting from selection of stable reference genes after hypoxia and hypothermia in the neonatal rat brain.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully recover from hypoxia episodes; however, some patients may develop HIE, leading to permanent neurological conditions or impairment of different organs and systems. Given its multifactor dependency, the timing, severity and outcome of this disease, mainly assessed through Sarnat staging, are of difficult evaluation. Moreover, although the latest newborn resuscitation guideline suggests the use of a 21% oxygen concentration or room air, such an approach is still under debate. Therefore, the pathological mechanism is still not clear and a golden standard treatment has yet to be defined. In this context, metabolomics, a new discipline that has described important perinatal issues over the last years, proved to be a useful tool for the monitoring, the assessment, and the identification of potential biomarkers associated with asphyxia events. This review covers metabolomics research on perinatal asphyxia condition, examining in detail the studies reported both on animal and human models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.