Evidence map›Paper›PMID 25898367›Full record

Trial reportPloS one2015

Structural brain changes after traditional and robot-assisted multi-domain cognitive training in community-dwelling healthy elderly.

Geon Ha Kim, Seun Jeon, Kiho Im, Hunki Kwon, Byung Hwa Lee, Ga Young Kim, Hana Jeong, Noh Eul Han, Sang Won Seo, Hanna Cho and 17 more

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01596205 (The Efficacy of Robot Assisted Group Cognitive Training in Elderly Adults Without Cognitive Impairment), which is not on this map. Cited by 46 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 13 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01596205 nacompletednot on this map

The Efficacy of Robot Assisted Group Cognitive Training in Elderly Adults Without Cognitive Impairment

TypeinterventionalSponsorSamsung Medical CenterRan2011 to 2012Enrolled85ConditionsAge-Related Cognitive DeclineArmsRobot assisted cognitive training, Conventional cognitive training group
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 13 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 12 institutions in 2 countries.

Geon Ha KimDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Seun JeonDepartment of Biomedical Engineering, Hanyang University, Seoul, Korea.
Kiho ImDivision of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachustetts, United States of America.
Hunki KwonDepartment of Biomedical Engineering, Hanyang University, Seoul, Korea.
Byung Hwa LeeDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ga Young KimDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hana JeongDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Noh Eul HanDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sang Won SeoDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Hanna ChoDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Young NohDepartment of Neurology, Gachon University Gil Medical Center, Incheon, Korea.
Sang Eon ParkSamsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Korea.
Hojeong KimSamsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Korea.
Jung Won HwangSamsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Korea.
Cindy W YoonDepartment of Neurology, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.
Hee Jin KimDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Byoung Seok YeDepartment of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Ju Hee ChinDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachustetts, United States of America.
Jung-Hyun KimDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Mee Kyung SuhDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jong Min LeeDepartment of Biomedical Engineering, Hanyang University, Seoul, Korea.
Sung Tae KimDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Mun-Taek ChoiSchool of Mechanical Engineering, Sungkyunkwan University, Seoul, Korea.
Mun Sang KimCenter for Intelligent Robotics at Korea Institute Science and Technology, Seoul, Korea.
Kenneth M HeilmanDepartment of Neurology, University of Florida College of Medicine, and the Veterans Affairs Medical Center, Gainesville, Florida, United States of America.
Jee Hyang JeongDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.
Duk L NaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sungkyunkwan University · KRSamsung Medical Center · KRHanyang University · KREwha Womans University · KRYonsei University · KRAsan Medical Center · KRFlorida College · USGachon University Gil Medical Center · KRHarvard University · USInha University Hospital · KRKorea Institute of Science and Technology · KRSamsung (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe purpose of this study was to investigate if multi-domain cognitive training, especially robot-assisted training, alters cortical thickness in the brains of elderly participants. A controlled trial was conducted with 85 volunteers without cognitive impairment who were 60 years old or older. Participants were first randomized into two groups. One group consisted of 48 participants who would receive cognitive training and 37 who would not receive training. The cognitive training group was randomly divided into two groups, 24 who received traditional cognitive training and 24 who received robot-assisted cognitive training. The training for both groups consisted of daily 90-min-session, five days a week for a total of 12 weeks. The primary outcome was the changes in cortical thickness. When compared to the control group, both groups who underwent cognitive training demonstrated attenuation of age related cortical thinning in the frontotemporal association cortices. When the robot and the traditional interventions were directly compared, the robot group showed less cortical thinning in the anterior cingulate cortices. Our results suggest that cognitive training can mitigate age-associated structural brain changes in the elderly.

trial registrationClnicalTrials.gov NCT01596205.

Indexed as

AgedBrainCognitionCognitive Behavioral TherapyDementiaFemaleHumansIndependent LivingMaleMiddle AgedOrgan SizeRoboticsTreatment Outcome

Identifiers

PMID25898367
PMCPMC4405358
OpenAlexW2063170297

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.