Evidence map›Paper›PMID 25898255›Full record

ArticlePloS one2015

Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.

Peter Arner, Frauke Henjes, Jochen M Schwenk, Spyros Darmanis, Ingrid Dahlman, Britt-Marie Iresjö, Peter Naredi, Thorhallur Agustsson, Kent Lundholm, Peter Nilsson and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Article
  12. Biomarkers for Cancer Cachexia: A Mini Review.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Biomarkers for cancer cachexia: where do we stand?Journal of cachexia, sarcopenia and muscle · 2020
    Article
  15. Article
  16. Serum Carnosinase-1 and Albuminuria Rather than theJournal of diabetes research · 2019
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Peter ArnerDepartment of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
Frauke HenjesAffinity Proteomics, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden.
Jochen M SchwenkAffinity Proteomics, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden.
Spyros DarmanisAffinity Proteomics, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden.
Ingrid DahlmanDepartment of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
Britt-Marie IresjöDepartment of Surgery, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden.
Peter NarediDepartment of Surgery, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden.
Thorhallur AgustssonDivision of Surgery, Department for Clinical Science, Intervention and Technology (CLINTEC), Södersjukhuset, 118 83, Stockholm, Sweden.
Kent LundholmDepartment of Surgery, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden.
Peter NilssonAffinity Proteomics, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden.
Mikael RydénDepartment of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
University of Gothenburg · SEKarolinska Institutet · SEKTH Royal Institute of Technology · SEScience for Life Laboratory · SEKarolinska University Hospital · SEStockholm South General Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer cachexia (CC) is linked to poor prognosis. Although the mechanisms promoting this condition are not known, several circulating proteins have been proposed to contribute. We analyzed the plasma proteome in cancer subjects in order to identify factors associated with cachexia. DESIGN/SUBJECTS: Plasma was obtained from a screening cohort of 59 patients, newly diagnosed with suspected gastrointestinal cancer, with (n = 32) or without (n = 27) cachexia. Samples were subjected to proteomic profiling using 760 antibodies (targeting 698 individual proteins) from the Human Protein Atlas project. The main findings were validated in a cohort of 93 patients with verified and advanced pancreas cancer.

resultsOnly six proteins displayed differential plasma levels in the screening cohort. Among these, Carnosine Dipeptidase 1 (CNDP1) was confirmed by sandwich immunoassay to be lower in CC (p = 0.008). In both cohorts, low CNDP1 levels were associated with markers of poor prognosis including weight loss, malnutrition, lipid breakdown, low circulating albumin/IGF1 levels and poor quality of life. Eleven of the subjects in the discovery cohort were finally diagnosed with non-malignant disease but omitting these subjects from the analyses did not have any major influence on the results.

conclusionsIn gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome. These results, together with recently published data demonstrating lower circulating CNDP1 in subjects with glioblastoma and metastatic prostate cancer, suggest that CNDP1 may constitute a marker of aggressive cancer and CC.

Indexed as

AdenocarcinomaAgedBiomarkers, TumorCachexiaCohort StudiesDipeptidasesFemaleHumansMaleMiddle AgedPrognosisStomach NeoplasmsSurvival AnalysisBiomarkers, TumorCNDP1 protein, humanDipeptidases

Identifiers

PMID25898255
PMCPMC4405487
OpenAlexW2031555656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.