Evidence map›Paper›PMID 25898185›Full record

ArticlePloS one2015

Risk factors for vitamin D deficiency among veterans with and without HIV infection.

Alicia I Hidron, Brittany Hill, Jodie L Guest, David Rimland

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Bone Loss in HIV Infection.Current treatment options in infectious diseases · 2017
    Article
  10. Vitamin D and bone loss in HIV.Current opinion in HIV and AIDS · 2016
    Review
  11. The protease inhibitors and HIV-associated bone loss.Current opinion in HIV and AIDS · 2016
    Review
  12. Article
  13. DUAL-ENERGY X-RAY ABSORPTIOMETRY AND CALCULATED FRAX RISK SCORES MAY UNDERESTIMATE OSTEOPOROTIC FRACTURE RISK IN VITAMIN D-DEFICIENT VETERANS WITH HIV INFECTION.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2016
    Article
  14. HYPOVITAMINOSIS D IN HIV-INFECTED PATIENTS.Acta endocrinologica (Bucharest, Romania : 2005)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Alicia I HidronAtlanta Veterans Affairs Medical Center, Decatur, Georgia, United States of America; Emory University School of Medicine, Atlanta, Georgia, United States of America; Universidad Pontificia Bolivariana, Medellín, Colombia; Hospital Pablo Tobón Uribe, Medellín, Colombia.
Brittany HillAtlanta Veterans Affairs Medical Center, Decatur, Georgia, United States of America; Winship Cancer Institute at Emory University, Atlanta, Georgia, United States of America.
Jodie L GuestAtlanta Veterans Affairs Medical Center, Decatur, Georgia, United States of America; Emory University School of Medicine, Atlanta, Georgia, United States of America; Rollins School of Public Health at Emory University, Atlanta, Georgia, United States of America.
David RimlandAtlanta Veterans Affairs Medical Center, Decatur, Georgia, United States of America; Emory University School of Medicine, Atlanta, Georgia, United States of America.
Emory University · USVeterans Health Administration · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
NIAID NIH HHS P30 AI050409
6 · The paper itself

Abstract

objectivesWe aimed to describe and compare the prevalence of vitamin D deficiency between HIV-negative and HIV-infected veterans in the southern United States, and to determine risk factors for vitamin D deficiency for HIV infected patients.

methodsCross-sectional, retrospective study including all patients followed at the Atlanta VA Medical Center with the first 25-hydroxyvitamin D [25(OH)D] level determined between January 2007 and August 2010. Multivariate logistic regression analysis was used to determine risk factors associated with vitamin D deficiency (< 20 ng/ml).

resultsThere was higher prevalence of 25(OH)D deficiency among HIV-positive compared to HIV-negative patients (53.2 vs. 38.5%, p <0.001). Independent risk factors for vitamin D deficiency in HIV + patients included black race (OR 3.24, 95% CI 2.28-4.60), winter season (OR 1.39, 95% CI 1.05-1.84) and higher GFR (OR 1.01, CI 1.00-1.01); increasing age (OR 0.98, 95% CI 0.95-0.98), and tenofovir use (OR 0.72, 95% CI 0.54-0.96) were associated with less vitamin D deficiency.

conclusionsVitamin D deficiency is a prevalent problem that varies inversely with age and affects HIV-infected patients more than other veterans in care. In addition to age, tenofovir and kidney disease seem to confer a protective effect from vitamin D deficiency in HIV-positive patients.

Indexed as

AdultAgedAged, 80 and overComorbidityCross-Sectional StudiesFemaleHIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedMultivariate AnalysisObesityRetrospective StudiesRisk FactorsVeterans

Identifiers

PMID25898185
PMCPMC4405192
OpenAlexW2012362442

What OpenQuestion holds

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LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.