Evidence map›Paper›PMID 25898121›Full record

ArticleClinical and experimental rheumatology

The impact of co-morbidity on health-related quality of life in rheumatoid arthritis and osteoarthritis patients.

Lorie L Geryk, Delesha M Carpenter, Susan J Blalock, Robert F DeVellis, Joanne M Jordan

Abstract readComparative Study
In one paragraph

Article in Clinical and experimental rheumatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  3. Health-related quality of life profiles of adults with arthritis and/or fibromyalgia: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lorie L GerykUNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, USA.
Delesha M CarpenterUNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, USA.
Susan J BlalockUNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, University of North Carolina, Chapel Hill, USA.
Robert F DeVellisUniversity of North Carolina, Gillings School of Global Public Health, Department of Health Behavior, University of North Carolina, Chapel Hill, USA.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina, Chapel Hill, USA.

Funding

UNC CLINICAL AND TRANSLATIONAL SCIENCE AWARD: BPCAUL1RR025747 · NCRR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2008 to 2011
$44.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
ARTHRITIS AND IMMUNOLOGYT32AR007416 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JORDAN, JOANNE M. · 1986 to 2009
$2.5M
NCRR NIH HHS UL1 RR025747NCRR NIH HHS UL1RR025747NIAMS NIH HHS T32 AR007416
6 · The paper itself

Abstract

objectivesWe investigated whether comorbidities differentially impacted health-related quality of life (HRQOL) for rheumatoid arthritis (RA) and osteoarthritis (OA) patients.

methodsAdult patients with self-reported doctor-diagnosed RA (n=159) or OA (n=149) were recruited from multiple sources and completed an online cross-sectional survey. Patients self-reported sociodemographic variables, arthritis severity and comorbid conditions. HRQOL was assessed using the SF-12v2 and comorbidity counts were assigned using an expanded Functional Comorbidities Index. HRQOL (8 domain and 2 composite (physical and mental health) scores) was compared with norm-based general US population scores and between RA and OA patients to determine if they significantly differed from one another. Linear regression was used to test whether comorbidity count was associated with the physical and mental health of RA and OA patients.

resultsOA and RA patients experienced significantly worse HRQOL across all dimensions compared with that of the general US population. There were no significant differences between RA and OA patients on any HRQOL dimension. A higher comorbidity count was associated with worse physical (p=0.0007) and mental (p=0.0295) health scores when controlling for patient gender, age, education, and arthritis severity.

conclusionsArthritis negatively impacted patients' HRQOL. OA patients in our sample perceived their condition as similarly disabling in terms of physical and mental health as RA patients. Arthritis patients with more chronic comorbid conditions may be at particular risk for poor physical and mental health. Providers should discuss management of comorbid conditions with arthritis patients.

Indexed as

Quality of LifeAdolescentAdultAgedArthritis, RheumatoidComorbidityCost of IllnessCross-Sectional StudiesFemaleHealth StatusHealth SurveysHumansInternetMaleMiddle AgedOsteoarthritis

Identifiers

PMID25898121
PMCPMC8985847

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.