ArticlePloS one2015
Risk factors for hospitalization due to community-acquired sepsis - a population-based case-control study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities.International journal for equity in health · 2024Pooled it
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- Early Sepsis Prediction Using Publicly Available Data: High-Performance AI/ML Models with First-Hour Clinical Information.Diagnostics (Basel, Switzerland) · 2025Article
- Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies.Critical care (London, England) · 2025Review
- Association of triglyceride glucose index with sepsis risk after major abdominal surgery: A retrospective cohort study.Pakistan journal of medical sciences · 2025Article
- Labour market attachment before and after hospitalisation for sepsis: a Danish cohort study.Critical care (London, England) · 2025Article
- Obesity as a Risk Factor in Pediatric Sepsis: A Retrospective Comparative Study Under the Phoenix Definition.Journal of clinical medicine · 2025Article
- Review
- Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis.Frontiers in genetics · 2024Article
- Major risk factors for Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study.BMC infectious diseases · 2023Article
- Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany - an ecological study.BMC public health · 2021Article
- A comparison of predictors for mortality and bacteraemia in patients suspected of infection.BMC infectious diseases · 2021Article
- Nationwide case-control study of risk factors and outcomes for community-acquired sepsis.Scientific reports · 2021Article
- Social determinants of health associated with the development of sepsis in adults: a scoping review protocol.BMJ open · 2020Article
- Clinical and microbiological characteristics and outcomes of community-acquired sepsis among adults: a single center, 1-year retrospective observational cohort study from Hungary.BMC infectious diseases · 2019Observational
- Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway.Intensive care medicine · 2018Article
- Dispatch and prehospital transport for acute septic patients: an observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2017Observational
- Recognition of sepsis in primary care: a survey among GPs.BJGP open · 2017Article
- Predicting emergency departments visit rates from septicemia in Taiwan using an age-period-cohort model, 1998 to 2012.Medicine · 2016Article
- Community-onset sepsis and its public health burden: protocol of a systematic review.Systematic reviews · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the study was to estimate risk factors for hospitalization due to sepsis and to determine whether these risk factors vary by age and gender.
methodsWe performed a population-based case-control study of all adult patients admitted to a medical ED from September 2010 to August 2011. Controls were sampled within the hospital catchment-area. All potential cases were manually validated using a structured protocol. Vital signs and laboratory values measured at arrival were registered to define systemic inflammatory response syndrome and organ dysfunction. Multivariable logistic regression was used to elucidate which predefined risk factors were associated with an increased or decreased risk hospitalization due to sepsis.
resultsA total of 1713 patients were admitted with sepsis of any severity. The median age was 72 years (interquartile range: 57-81 years) and 793 (46.3%) were male. 621 (36.3%) patients were admitted with sepsis, 1071 (62.5%) with severe sepsis and 21 (1.2%) with septic shock. Episodes with sepsis of any severity were associated with older age (85+ years adjusted OR 6.02 [95%CI: 5.09-7.12]), immunosuppression (4.41 [3.83-5.09]), alcoholism-related conditions (2.90 [2.41-3.50]), and certain comorbidities: psychotic disorder (1.90 [1.58-2.27]), neurological (1.98 [1.73-2.26]), respiratory (3.58 [3.16-4.06]), cardiovascular (1.62 [1.41-1.85]), diabetes (1.82 [1.57-2.12]), cancer (1.44 [1.22-1.68]), gastrointestinal (1.71 [1.44-2.05]) and renal (1.46 [1.13-1.89]). The strength of the observed associations for comorbid factors was strongest among younger individuals.
conclusionsHospitalization due to sepsis of any severity was associated with several independent risk factors, including age and comorbid factors.
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