Evidence map›Paper›PMID 25897948›Full record

SynthesisBreast cancer research : BCR2015

Common germline polymorphisms associated with breast cancer-specific survival.

Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer and 139 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Breast cancer research : BCR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Mutations inJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Article
  8. Article
  9. Breast Cancer-Related Low Penetrance Genes.Advances in experimental medicine and biology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

149 authors.

Ailith PirieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ap736@medschl.cam.ac.uk.
Qi GuoCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. qg209@medschl.cam.ac.uk.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. pkraft@hsph.harvard.edu.
Sander CanisiusNetherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. s.canisius@nki.nl.
Diana M EcclesFaculty of Medicine, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK. d.m.eccles@soton.ac.uk.
Nazneen RahmanDivision of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, UK. Nazneen.Rahman@icr.ac.uk.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
Constance ChenProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. cjchen@hsph.harvard.edu.
Sofia KhanDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. sofia.khan@helsinki.fi.
Jonathan TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. jpt34@medschl.cam.ac.uk.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. mkh39@medschl.cam.ac.uk.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. qw232@medschl.cam.ac.uk.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. jgd29@cam.ac.uk.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. km533@medschl.cam.ac.uk.
Michael LushCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. mjl81@medschl.cam.ac.uk.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. amd24@medschl.cam.ac.uk.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ms483@medschl.cam.ac.uk.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. kamila.czene@ki.se.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. hatef.darabi@ki.se.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. mikael.eriksson@ki.se.
Dieter LambrechtsVesalius Research Center (VRC), Vib, Herestraat 49, 3000, Leuven, Belgium. diether.lambrechts@med.kuleuven.be.
Caroline WeltensOncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. caroline.weltens@uzleuven.be.
Karin LeunenOncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. karin.leunen@uzleuven.be.
Chantal van OngevalOncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. Chantal.VanOngeval@uzleuven.be.
Børge G NordestgaardCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. boerge.nordestgaard@regionh.dk.
Sune F NielsenCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. sune.fallgaard.nielsen@regionh.dk.
Henrik FlygerDepartment of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. henrik.flyger@regionh.dk.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.rudolph@dkfz.de.
Petra SeiboldDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. p.seibold@dkfz.de.
Dieter Flesch-JanysDepartment of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. flesch@uke.uni-hamburg.de.
Carl BlomqvistDepartment of Oncology, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. carl.blomqvist@helsinki.fi.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. kristiina.aittomaki@hus.fi.
Rainer FagerholmDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
Taru A MuranenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. taru.a.muranen@helsinki.fi.
Janet E OlsenDepartment of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olsonj@mayo.edu.
Emily HallbergDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Hallberg.emily@mayo.edu.
Celine VachonDepartment of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. vachon.celine@mayo.edu.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. knight@lunenfeld.ca.
Gord GlendonOntario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. gglendon@uhnresearch.ca.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. AnnaMarie.Mulligan@uhn.ca.
Annegien BroeksNetherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. a.broeks@nki.nl.
Sten CornelissenNetherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. s.cornelissen@nki.nl.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. Christopher.Haiman@med.usc.edu.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. Behender@usc.edu.
Frederick SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. fschumac@usc.edu.
Loic Le MarchandCancer Research Center of Hawaii, University of Hawaii, 701 Ilalo Street, Honolulu, HI, 96813, USA. loic@crch.hawaii.edu.
John L HopperCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. j.hopper@unimelb.edu.au.
Helen TsimiklisDepartment of Pathology, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. htsi@unimelb.edu.au.
Carmel ApicellaCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. capic@unimelb.edu.au.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. msouthey@unimelb.edu.au.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. s.s.cross@sheffield.ac.uk.
Malcolm Wr ReedCRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK. m.w.reed@sheffield.ac.uk.
Graham G GilesCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Graham.Giles@cancervic.org.au.
Roger L MilneCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Roger.Milne@cancervic.org.au.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Commercial Road, Melbourne, VIC, 3007, Australia. C.McLean@alfred.org.au.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland. robert.winqvist@oulu.fi.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland. katri.pylkas@oulu.fi.
Arja Jukkola-VuorinenDepartment of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220, Oulu, Finland. arja.jukkola-vuorinen@ppshp.fi.
Mervi GripDepartment of Surgery, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220, Oulu, Finland. mervi.grip@ppshp.fi.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. m.hooning@erasmusmc.nl.
Antoinette HollestelleDepartment of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.hollestelle@erasmusmc.nl.
John Wm MartensDepartment of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.martens@erasmusmc.nl.
Ans Mw van den OuwelandDepartment of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.vandenouweland@erasmusmc.nl.
Federick MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. frederikmarme@gmail.com.
Andreas SchneeweissDepartment of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. Andreas.Schneeweiss@med.uni-heidelberg.de.
Rongxi YangDepartment of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. R.Yang@dkfz.de.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. Barbara.Burwinkel@med.uni-heidelberg.de.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. figueroaj@mail.nih.gov.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. chanocks@mail.nih.gov.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentena 5, 02-781, Warsaw, Poland. lissowsj@coi.waw.pl.
Elinor J SawyerDivision of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust in Partnership with King's College London, Guy's Campus, SE1 1UL, London, UK. chanocks@mail.nih.gov.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. iant@well.ox.ac.uk.
Michael J KerinClinical Science Institute, University Hospital Galway, Newcastle Road, Galway, Ireland. michael.kerin@nuigalway.ie.
Nicola MillerClinical Science Institute, University Hospital Galway, Newcastle Road, Galway, Ireland. nicola.miller@nuigalway.ie.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. h.brenner@dkfz.de.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. k.butterbach@dkfz.de.
Bernd HolleczekSaarland Cancer Registry, Präsident Baltz Strasse 5, 66119, Saarbrücken, Germany. b.holleczek@gbe-ekr.saarland.de.
Vesa KatajaSchool of Medicine, Institute of Clinical Medicine, Oncology and Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. vesa.kataja@kuh.fi.
Veli-Matti KosmaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. veli-matti.kosma@uef.fi.
Jaana M HartikainenSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. jaana.hartikainen@uef.fi.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. jingmei@gmail.com.
Judith S BrandDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. judith.brand@ki.se.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. Keith.Humphreys@ki.se.
Peter DevileeDepartment of Human Genetics and Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. p.devilee@lumc.nl.
Robert Aem TollenaarDepartment of Surgical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. r.a.e.m.tollenaar@lumc.nl.
Caroline SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. c.seynaeve@erasmusmc.nl.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), Via Adamello 16, Milan, 20139, Italy. paolo.radice@istitutotumori.mi.it.
Paolo PeterlongoIFOM, Fondazione Istituto FIRC Di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. paolo.peterlongo@ifom.eu.
Siranoush ManoukianUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), Via Adamello 16, Milan, 20139, Italy. siranoush.manoukian@istitutotumori.mi.it.
Filomena FicarazziIFOM, Fondazione Istituto FIRC Di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. filomena.ficarazzi@ifom.eu.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. fk-direktion@uk-erlangen.de.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. alexander.hein@uk-erlangen.de.
Arif B EkiciInstitute of Human Genetics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. arif.ekici@uk-erlangen.de.
Rosemary BalleineWestern Sydney and Nepean Blue Mountains Local Health Districts, Westmead Millennium Institute for Medical Research, University of Sydney, 176 Hawkesbury Road, Sydney, NSW 2145, Australia. rosemary.balleine@sydney.edu.au.
Kelly-Anne PhillipsCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Kelly.Phillips@petermac.org.
kConFab Investigators
Javier BenitezHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández, Almagro, 3, 28029, Madrid, Spain. jbenitez@cnio.es.
M Pilar ZamoraServicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain. zamorapilar@gmail.com.
Jose Ignacio Arias PerezServicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avenida Doctores Fernández Vega, 107, 33012, Oviedo, Spain. jiarias@msn.com.
Primitiva MenéndezServicio de Anatomía Patológica, Hospital Monte Naranco, Avenida Doctores Fernández Vega, 107, 33012, Oviedo, Spain. tiva@hca.es.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. aniaj@sci.pam.szczecin.pl.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. lubinski@sci.pam.szczecin.pl.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. jgron@sci.pum.edu.pl.
Katarzyna DurdaDepartment of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. k.durda@onet.pl.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
Maria KabischMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. m.kabisch@dkfz-heidelberg.de.
Hans Ulrich UlmerFrauenklinik der Stadtklinik Baden-Baden, Balger Strasse 50, 76532, Baden-Baden, Germany. hu.ulmer@klinikum-mittelbaden.de.
Thomas RüdigerInstitute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133, Karlsruhe, Germany. Thomas.Ruediger@klinikum-karlsruhe.de.
Sara MargolinDepartment of Oncology - Pathology, Karolinska Institutet, Tomtebodavägen 23b, Stockholm, 171 65, Sweden. Sara.Margolin@karolinska.se.
Vessela KristensenFaculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Problemveien 7, Oslo, 0313, Norway. Vessela.N.Kristensen@rr-research.no.
Siljie NordFaculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Problemveien 7, Oslo, 0313, Norway. silje.nordgard@gmail.com.
NBCS Investigators
D Gareth EvansGenomic Medicine, Manchester Academic Health Science Centre, University of Manchester, Central Manchester Foundation Trust, St. Mary's Hospital, Oxford Road, Manchester, M13 9WL, UK. Gareth.Evans@cmft.nhs.uk.
Jean AbrahamCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ja344@medschl.cam.ac.uk.
Helena EarlCambridge Experimental Cancer Medicine Centre, Robinson Way, Cambridge, CB2 0RE, UK. hme22@cam.ac.uk.
Christopher J PooleWarwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. christopher.poole@warwick.ac.uk.
Louise HillerWarwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. l.hiller@warwick.ac.uk.
Janet A DunnWarwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. j.a.dunn@warwick.ac.uk.
Sarah BowdenCancer Research UK Clinical Trials Unit, Institute for Cancer Studies, the University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK. s.j.bowden@bham.ac.uk.
Rose YangEarly Detection Research Group, Division of Cancer Prevention National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892, USA. royang@mail.nih.gov.
Daniele CampaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. d.campa@dkfz-heidelberg.de.
W Ryan DiverEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Ryan.diver@cancer.org.
Susan M GapsturEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Susan.gapstur@cancer.org.
Mia M GaudetEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Mia.gaudet@cancer.org.
Susan HankinsonDepartment of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. shankinson@schoolph.umass.edu.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. hooverr@exchange.nih.gov.
Anika HüsingDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.huesing@dkfz.de.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. r.kaaks@dkfz.de.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. Mitchell.machiela@nih.gov.
Walter WillettDepartment of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, USA. wwillett@hsph.harvard.edu.
Myrto BarrdahlDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. m.barrdahl@Dkfz-Heidelberg.de.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. f.canzian@dkfz-heidelberg.de.
Suet-Feung ChinBreast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, CB2 0RE, UK. Suet-Feung.Chin@cruk.cam.ac.uk.
Carlos CaldasCambridge Experimental Cancer Medicine Centre, Robinson Way, Cambridge, CB2 0RE, UK. carlos.caldas@cruk.cam.ac.uk.
David J HunterDepartment of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. dhunter@hsph.harvard.edu.
Sara LindstromDepartment of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. slindstr@hsph.harvard.edu.
Montserrat Garcia-ClosasDivision of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, UK. Montse.GarciaClosas@icr.ac.uk.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. couch.fergus@mayo.edu.
Georgia Chenevix-TrenchDepartment of Genetics, Qimr Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia. Georgia.Trench@qimrberghofer.edu.au.
Arto MannermaaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. arto.mannermaa@uef.fi.
Irene L AndrulisOntario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. andrulis@lunenfeld.ca.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. Per.Hall@ki.se.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. j.chang-claude@dkfz-heidelberg.de.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
Stig E BojesenCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
Angela CoxCRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK. a.cox@shef.ac.uk.
Peter A FaschingInstitute of Human Genetics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. peter.fasching@uk-erlangen.de.
Paul Dp PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. pp10001@medschl.cam.ac.uk.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. mk.schmidt@nki.nl.

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Northern California Cooperative Family Registry for Breast CancerU01CA069417 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M. · 1995 to 2010
$22.4M
Core-001U01CA164920 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Irene Andrulis, Sarah Violet Colonna · 2018 to 2026
$17.0M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Understanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098233 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 2003 to 2010
$10.8M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098216 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI RIBOLI, ELIO · 2003 to 2011
$7.4M
Cancer Research UK 10124Cancer Research UK 15106Cancer Research UK 15958Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 16942NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA122340NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA132839NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA069638NCI NIH HHS U01 CA098216NCI NIH HHS U01 CA098233NCI NIH HHS U01 CA098710NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA164920NCI NIH HHS U19 CA148065NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA164973
6 · The paper itself

Abstract

introductionPrevious studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium.

methodsA literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect.

resultsFifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease.

conclusionsAlthough no variants reached genome-wide significance (P <5 x 10(-8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

Indexed as

Polymorphism, Single NucleotideBreast NeoplasmsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGerm CellsHumansPrognosis

Identifiers

PMID25897948
PMCPMC4484708

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