ArticleLab animal2015
Postoperative pain in Sprague Dawley rats after liver biopsy by laparotomy versus laparoscopy.
Article in Lab animal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
- Induction of Endometriosis in a Menstruating Mouse Model (Mus musculus): A Translational Animal Disease Model.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- The grimace scale: a useful tool for assessing pain in laboratory animals.Experimental animals · 2024Review
- Laparoscopic treatment of congenital portosystemic shunts with portal pressure measurement and portal angiography in 36 dogs.Frontiers in veterinary science · 2024Article
- Laparoscopic-Assisted Colorectal Resection Can Reduce the Inhibition of Immune Function Compared with Conventional Open Surgery: A Retrospective Clinical Study.Journal of clinical medicine · 2023Article
- Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model.World journal of gastroenterology · 2021Article
- Grimace Scores: Tools to Support the Identification of Pain in Mammals Used in Research.Animals : an open access journal from MDPI · 2020Review
- Use of the Rat Grimace Scale to Evaluate Neuropathic Pain in a Model of Cervical Radiculopathy.Comparative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laparoscopic surgery offers advantages for both animal welfare and quality of experimental data. Compared with laparotomy, laparoscopy is associated with less postoperative pain and faster recuperation in humans and is also associated with less postoperative pain in dogs. Postoperative pain associated with laparotomy and laparoscopy has not been compared in rodents, however. The authors used a validated pain grimace scale to evaluate postoperative pain in male Sprague Dawley rats after liver biopsy by laparotomy or laparoscopy. Rats that underwent laparoscopy showed fewer recognized signs of pain than did rats that underwent laparotomy. The authors suggest that laparoscopy could be used for repeated biopsies in rats, minimizing the number of animals used in pharmacological and toxicological studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.