ArticlePloS one2015
From broad-spectrum biocides to quorum sensing disruptors and mussel repellents: antifouling profile of alkyl triphenylphosphonium salts.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Phosphonium-based disinfectants are as effective as best-in-class quaternary ammonium compounds in the eradication of established biofilms in antibiotic-resistant bacteria.Microbiology spectrum · 2026Article
- Cabomba caroliniana and Schoenoplectus californicus as Antifouling Candidates: Anti-Attachment and Toxicological Effects in Aurelia coerulea (Cnidaria, Scyphozoa).Environmental toxicology · 2026Article
- Preference by the Nymphs of Americabaetis alphus Lugo-Ortiz & McCafferty, 1996 (Baetidae: Ephemeroptera) for Feeding substrate and Food Size Under Laboratory Conditions.Neotropical entomology · 2026Article
- Corrosion and Antifouling Behavior of a New Biocide-Free Antifouling Paint for Ship Hulls Under Both Artificially Simulated and Natural Marine Environment.Materials (Basel, Switzerland) · 2025Article
- Antifouling Mussel-Inspired Hydrogel with Furanone-Loaded ZIF-8 for Quorum Sensing-Mediated Marine Antifouling.Gels (Basel, Switzerland) · 2025Article
- Shifting from Ammonium to Phosphonium Salts: A Promising Strategy to Develop Next-Generation Weapons against Biofilms.Pharmaceutics · 2024Review
- Amide/Amino-Based Functional Additives for Lubricants: Structure, Antimicrobial Activity and Wear Resistance.Molecules (Basel, Switzerland) · 2023Article
- Bioactive Peptides from Barnacles and Their Potential for Antifouling Development.Marine drugs · 2023Review
- Impact of flow regime on the performance of anti-biofouling coatings.Scientific reports · 2023Article
- Ship Hull-Fouling Diatoms on Korean Research Vessels Revealed by Morphological and Molecular Methods, and Their Environmental Implications.Journal of microbiology (Seoul, Korea) · 2023Article
- Exploring Efflux as a Mechanism of Reduced Susceptibility towards Biocides and Fluoroquinolones inAnimals : an open access journal from MDPI · 2023Article
- Article
- Article
- A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.Angewandte Chemie (International ed. in English) · 2022Article
- Application of poly(vinylphosphonic acid) modified poly(amidoxime) in uptake of uranium from seawater.RSC advances · 2022Article
- Sterically Hindered Quaternary Phosphonium Salts (QPSs): Antimicrobial Activity and Hemolytic and Cytotoxic Properties.International journal of molecular sciences · 2021Article
- Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties.Molecules (Basel, Switzerland) · 2021Article
- Flavonoid Glycosides with a Triazole Moiety for Marine Antifouling Applications: Synthesis and Biological Activity Evaluation.Marine drugs · 2020Article
- Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones.Biomolecules · 2020Article
- Biomimetic Approaches for the Development of New Antifouling Solutions: Study of Incorporation of Macroalgae and Sponge Extracts for the Development of New Environmentally-Friendly Coatings.International journal of molecular sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
'Onium' compounds, including ammonium and phosphonium salts, have been employed as antiseptics and disinfectants. These cationic biocides have been incorporated into multiple materials, principally to avoid bacterial attachment. In this work, we selected 20 alkyl-triphenylphosphonium salts, differing mainly in the length and functionalization of their alkyl chains, in fulfilment of two main objectives: 1) to provide a comprehensive evaluation of the antifouling profile of these molecules with relevant marine fouling organisms; and 2) to shed new light on their potential applications, beyond their classic use as broad-spectrum biocides. In this regard, we demonstrate for the first time that these compounds are also able to act as non-toxic quorum sensing disruptors in two different bacterial models (Chromobacterium violaceum and Vibrio harveyi) as well as repellents in the mussel Mytilus galloprovincialis. In addition, their inhibitory activity on a fouling-relevant enzymatic model (tyrosinase) is characterized. An analysis of the structure-activity relationships of these compounds for antifouling purposes is provided, which may result useful in the design of targeted antifouling solutions with these molecules. Altogether, the findings reported herein provide a different perspective on the biological activities of phosphonium compounds that is particularly focused on, but, as the reader will realize, is not limited to their use as antifouling agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.