ArticlePloS one2015
Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulating irisin levels in patients with MAFLD: an updated systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet.Medicina (Kaunas, Lithuania) · 2024Trial
- The effect of supervised aerobic exercise on adipokine and myokine biomarkers in patients with cancer during systemic chemotherapy: a single-blinded prospective controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Sarcopenic obesity: a review.Archives of endocrinology and metabolism · 2025Review
- Irisin promotes intestinal epithelial cell proliferation via Wnt/β-catenin and focal adhesion kinase signaling pathways.Scientific reports · 2024Article
- Article
- The Effect of Exercise Training on Irisin Secretion in Patients with Type 2 Diabetes: A Systematic Review.Journal of clinical medicine · 2022Review
- Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis.Diabetology & metabolic syndrome · 2022Article
- Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease.Journal of clinical medicine · 2022Article
- Review
- Do skeletal muscle composition and gene expression as well as acute exercise-induced serum adaptations in older adults depend on fitness status?BMC geriatrics · 2021Article
- Article
- Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence.International journal of molecular sciences · 2021Review
- Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging.International journal of molecular sciences · 2021Review
- Thyroid hormones modulate irisin concentrations in patients with recently onset hypothyroidism following total thyroidectomy.Journal of endocrinological investigation · 2021Article
- Review
- Biomarkers of Angiogenesis and Neuroplasticity as Promising Clinical Tools for Stroke Recovery Evaluation.International journal of molecular sciences · 2021Review
- The role of Irisin in multiorgan protection.Molecular biology reports · 2021Review
- Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise.Frontiers in physiology · 2021Review
- Myokines in Acromegaly: An Altered Irisin Profile.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various metabolic parameters in humans.
methodsCirculating irisin levels (ELISA) and metabolic parameters were analyzed in 428 subjects (195 men/233 women). Participants were classified according to their self-reported physical activity and to their area of residence.
resultsCirculating irisin levels were higher in active than in sedentary subjects (p = 0.006). Rural inhabitants showed higher circulating irisin levels than urban subjects (p < 0.0001). The increase in irisin levels related to an active lifestyle was only observed in rural citizens (p = 0.014). Among sedentary participants, irisin levels were positively associated with metabolic risk factors (BMI, fasting insulin, HOMA and fasting triglycerides). The area of residence (β = - 0.592, p = < 0.0001) contributed independently to circulating irisin levels variance after controlling for age, gender, BMI, HOMAIR, triglycerides and physical activity.
conclusionsIn sedentary participants, circulating irisin levels were positively associated with parameters related to an increased cardiometabolic risk. The present study confirmed that an active lifestyle increases circulating irisin levels, but only among subjects living in a rural environment. Area of residence might be a determinant of irisin levels.
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