ArticlePediatric research2015
Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prenatal stress and externalizing behaviors in childhood and adolescence: A systematic review and meta-analysis.Psychological bulletin · 2024Pooled it
- Exercise and yoga during pregnancy and their impact on depression: a systematic literature review.Archives of women's mental health · 2022Pooled it
- Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review.The Journal of clinical psychiatry · 2020Pooled it
- Pooled it
- Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.Current topics in behavioral neurosciences · 2025Review
- Fluoxetine exposure alters behavior and morphology ofmicroPublication biology · 2025Article
- Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression.Frontiers in cell and developmental biology · 2024Article
- Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: A review of the literature and description of a study protocol for a register-based cohort study.Reproductive toxicology (Elmsford, N.Y.) · 2023Review
- Prenatal Selective Serotonin Reuptake Inhibitor Exposure, Depression, and Brain Morphology in Middle Childhood: Results From the ABCD Study.Biological psychiatry global open science · 2023Article
- Article
- Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy.Scientific reports · 2022Article
- Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022Article
- Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders.Translational psychiatry · 2021Review
- Prenatal antidepressant exposure and child development at kindergarten age: a population-based study.Pediatric research · 2021Article
- Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.Scientific reports · 2021Article
- Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation.Frontiers in psychiatry · 2021Article
- Perinatal fluoxetine treatment and dams' early life stress history have opposite effects on aggressive behavior while having little impact on sexual behavior of male rat offspring.Psychopharmacology · 2020Article
- Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAnimal research has suggested that prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure causes increased anxiety-like behaviors in adulthood. We examined whether in utero SRI exposure influenced externalizing and internalizing behaviors in children at 3 y and again at 6 y of age.
methodsWe recruited women in their second trimester of pregnancy from primary maternity care providers in Vancouver British Columbia, Canada. We compared the internalizing, externalizing, and the anxious and attention subscales of the internalizing behaviors scores of children exposed to SRIs and children not exposed to SRIs at age 3 and age 6.
resultsWe included 110 mother-child pairs (44 exposed to SRI and 66 not exposed). Higher levels of internalizing and anxious behaviors were reported in SRI exposed children at both 3 and 6 y of age compared with children who were not exposed (F = 7.52, P = 0.0072 and F = 7.91, P = 0.0058, respectively). The fully adjusted hierarchical regression models indicated a positive and significant relationship between SRI exposure and increased internalizing and anxious behaviors even when controlling for maternal mood during pregnancy, postpartum and childhood.
conclusionSRI exposure was associated with sustained higher levels of internalizing behaviors in early childhood even when controlling for maternal depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.