Optogenetic induced epileptiform activity in a model human cortex.

Prashanth Selvaraj, Jamie W Sleigh, Heidi E Kirsch, Andrew J Szeri

Open access · diamondAbstract read

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Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics.eLife · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Prashanth SelvarajDepartment of Mechanical Engineering, University of California, Berkeley, 94720 CA USA.

Jamie W SleighWaikato Clinical School, University of Auckland, Hamilton, New Zealand.

Heidi E KirschDepartments of Neurology and Radiology and Biomedical Imaging, University of California, San Francisco, 94143 CA USA.

Andrew J SzeriDepartment of Mechanical Engineering, University of California, Berkeley, 94720 CA USA ; Center for Neural Engineering and Prosthesis, University of California, Berkeley, 94720 CA USA.

University of California, Berkeley · USUniversity of Auckland · NZUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCortical stimulation plays an important role in the study of epileptic seizures. We present a numerical simulation of stimulation using optogenetic channels expressed by excitatory cells in a mean field model of the human cortex.

findingsDepolarising excitatory cells in a patch of model cortex using Channelrhodpsin-2 (ChR2) ion channels, we are able to hyper-excite a normally functioning cortex and mimic seizure activity. The temporal characteristics of optogenetic channels, and the ability to control the frequency of synchronous activity using these properties are also demonstrated.

conclusionsOptogenetics is a powerful stimulation technique with high spatial, temporal and cell-type specificity, and would be invaluable in studying seizures and other brain disorders and functions.

Indexed as

Epiletic seizure propagationMeso-scale cortical modelOptogenetic stimulation

Identifiers

PMID25897410

DOI10.1186/s40064-015-0836-7

PMCPMC4395626

OpenAlexW2102710698

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.