ReviewWorld journal of diabetes2015
Nociception at the diabetic foot, an uncharted territory.
Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prevention, assessment, diagnosis and management of diabetic foot based on clinical practice guidelines: A systematic review.Medicine · 2019Pooled it
- Key challenges in nurse-led foot care education for persons with diabetes: an international survey across six countries.BMC nursing · 2026Article
- Trial of a Trivial Quantitative Heat-Pain Stimulus for Detecting Severe Loss of Nociception.Journal of diabetes science and technology · 2024Article
- Peripheral Arterial Disease and the Diabetic Foot Syndrome: Neuropathy Makes the Difference! A Narrative Review.Journal of clinical medicine · 2024Review
- Photothermal Controlled-Release Immunomodulatory Nanoplatform for Restoring Nerve Structure and Mechanical Nociception in Infectious Diabetic Ulcers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential.Frontiers in cellular neuroscience · 2022Review
- Practices followed by type-II diabetes mellitus patients for prevention of foot ulcers.Journal of family medicine and primary care · 2021Article
- [Diabetic foot syndrome-Part 1 : Definition, pathophysiology, diagnostics and classification].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Article
- Adipose stem cells isolated from diabetic mice improve cutaneous wound healing in streptozotocin-induced diabetic mice.Stem cell research & therapy · 2020Article
- Prevalence and Risk Factors of Sensory Symptoms in Diabetes Patients in Taiwan.Frontiers in endocrinology · 2020Article
- Diabetic Foot Ulcers: Current Advances in Antimicrobial Therapies and Emerging Treatments.Antibiotics (Basel, Switzerland) · 2019Review
- Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.Nature communications · 2019Article
- Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?Neuroscience letters · 2018Article
- Patients with type 2 diabetes demonstrate proprioceptive deficit in the knee.World journal of diabetes · 2018Article
- Imaging of the spectrum of bony injuries in the diabetic foot: a case series with emphasis on non-Charcot fractures.BJR case reports · 2017Article
- Conventional deep pressure algometry is not suitable for clinical assessment of nociception in painless diabetic neuropathy.Diabetic foot & ankle · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diabetic foot is characterised by painless foot ulceration and/or arthropathy; it is a typical complication of painless diabetic neuropathy. Neuropathy depletes the foot skin of intraepidermal nerve fibre endings of the afferent A-delta and C-fibres, which are mostly nociceptors and excitable by noxious stimuli only. However, some of them are cold or warm receptors whose functions in diabetic neuropathy have frequently been reported. Hence, it is well established by quantitative sensory testing that thermal detection thresholds at the foot skin increase during the course of painless diabetic neuropathy. Pain perception (nociception), by contrast, has rarely been studied. Recent pilot studies of pinprick pain at plantar digital skinfolds showed that the perception threshold was always above the upper limit of measurement of 512 mN (equivalent to 51.2 g) at the diabetic foot. However, deep pressure pain perception threshold at musculus abductor hallucis was beyond 1400 kPa (equivalent to 14 kg; limit of measurement) only in every fifth case. These discrepancies of pain perception between forefoot and hindfoot, and between skin and muscle, demand further study. Measuring nociception at the feet in diabetes opens promising clinical perspectives. A critical nociception threshold may be quantified (probably corresponding to a critical number of intraepidermal nerve fibre endings), beyond which the individual risk of a diabetic foot rises appreciably. Staging of diabetic neuropathy according to nociception thresholds at the feet is highly desirable as guidance to an individualised injury prevention strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.