ArticleClinical, cosmetic and investigational dermatology2015
Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality.
Article in Clinical, cosmetic and investigational dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Evaluation of the Performance and Safety of a New Micro-Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A Randomized Split Face/Neck Study.Journal of cosmetic dermatology · 2024Trial
- Mechanistic and Preliminary Safety Profiling of a Multicomponent Natural Product-Based Injectable Formulation Targeting Skin Aging-Related Pathways: A Network Pharmacology and Single-Dose Toxicity Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Effects of New Cellular Treatment Factor and Human Exosome Injection on Intact Skin Regeneration in a Randomized In Vivo Study.Plastic and reconstructive surgery. Global open · 2026Article
- Effects of Polyrevitalising Solution Injections Combined With Facelift Surgery on Facial Scar Healing and Skin Quality: A Split-Face Pilot Study.Aesthetic surgery journal. Open forum · 2026Article
- Facial Skin Density Enhancement Using Hyaluronic Acid-Based Bioactive Hydrogel: Cannula-Assisted Delivery and Ultrasound Evaluation in a Retrospective Controlled Study.Pharmaceutics · 2025Article
- Article
- An International Survey on the Use of a Polyrevitalizing Solution With or Without Other Aesthetic Procedures in the Daily Practice of Aesthetic Physicians.Journal of cosmetic dermatology · 2025Article
- Article
- Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview.Archives of plastic surgery · 2024Article
- The efficacy of hyaluronic acid fragments with amino acid in combating facial skin aging: an ultrasound and histological study.Journal of ultrasound · 2024Article
- Novel approach to soft tissue regeneration: in vitro study of compound hyaluronic acid and horizontal platelet-rich fibrin combination.Journal of applied oral science : revista FOB · 2024Article
- Ex Vivo Functional Benchmarking of Hyaluronan-Based Osteoarthritis Viscosupplement Products: Comprehensive Assessment of Rheological, Lubricative, Adhesive, and Stability Attributes.Gels (Basel, Switzerland) · 2023Article
- A Subjective and Objective Assessment of Combined Methods of Applying Chemical Peels and Microneedling in Antiaging Treatments.Journal of clinical medicine · 2023Article
- Depth of Treatment in the Facial Rejuvenation: The Neglected Point in Facial Mesotherapy.Journal of plastic and reconstructive surgery · 2023Article
- The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review.Clinical, cosmetic and investigational dermatology · 2023Review
- In Vitro Evaluation of the Effect of a Not Cross-Linked Hyaluronic Acid Hydrogel on Human Keratinocytes for Mesotherapy.Gels (Basel, Switzerland) · 2021Article
- An Overview of Soft Tissue Fillers for Cosmetic Dermatology: From Filling to Regenerative Medicine.Clinical, cosmetic and investigational dermatology · 2021Review
- Therapeutic effect of concentrated growth factor preparation on skin photoaging in a mouse model.The Journal of international medical research · 2020Article
- Safety evaluation and consideration of 4 Pin Multi-needle for meso-therapy.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018Article
- Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage.Drug delivery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging can largely be attributed to dermal fibroblast dysfunction and a decrease in their biosynthetic activity. Regardless of the underlying causes, aging fibroblasts begin to produce elements of the extracellular matrix in amounts that are insufficient to maintain the youthful appearance of skin. The goal of mesopreparations is primarily to slow down and correct changes in skin due to aging. The rationale for developing complex polycomponent mesopreparations is based on the principle that aging skin needs to be supplied with the various substrates that are key to the adequate functioning of the fibroblast. The quintessential example of a polycomponent formulation - NCTF(®) (New Cellular Treatment Factor) - includes vitamins, minerals, amino acids, nucleotides, coenzymes and antioxidants, as well as hyaluronic acid, designed to help fibroblasts function more efficiently by providing a more optimal environment for biochemical processes and energy generation, as well as resisting the effects of oxidative stress. In vitro experiments suggest that there is a significant increase in the synthetic and prophylactic activity of fibroblasts with treated NCTF, and a significant increase in the ability of cells to resist oxidative stress. The current article looks at the rationale behind the development of polycomponent mesopreparations, using NCTF as an example.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.