Evidence map›Paper›PMID 25897216›Full record

ReviewInternational journal of chronic obstructive pulmonary disease2015

A review of the most common patient-reported outcomes in COPD--revisiting current knowledge and estimating future challenges.

Mario Cazzola, Nicola Alexander Hanania, William MacNee, Katja Rüdell, Claire Hackford, Nihad Tamimi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Prevention of COPD exacerbation by lysozyme: a double-blind, randomized, placebo-controlled study.International journal of chronic obstructive pulmonary disease · 2016
    Trial
  8. Construct Validity Matters: Are CAT and 5STS Surrogates of Exercise Capacity in COPD? [Letter].International journal of chronic obstructive pulmonary disease · 2026
    Article
  9. Article
  10. Real-World Evaluation of an EHR-Enabled Chronic Obstructive Pulmonary Disease Assessment Test.International journal of chronic obstructive pulmonary disease · 2025
    Observational
  11. Article
  12. Article
  13. Article
  14. Urine and Plasma Markers of Platelet Activation and Respiratory Symptoms in COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Future concepts in bronchodilation for COPD: dual-European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mario CazzolaUniversity of Rome 'Tor Vergata', Department of Medicine of Systems, Unit of Respiratory Clinical Pharmacology, Rome, Italy.
Nicola Alexander HananiaSection of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
William MacNeeUniversity of Edinburgh/MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Katja RüdellPatient Reported Outcome Center of Excellence, Global Market Access, Primary Care Business Unit, Pfizer, Tadworth, United Kingdom.
Claire HackfordPatient Reported Outcome Center of Excellence, Global Market Access, Primary Care Business Unit, Pfizer, Tadworth, United Kingdom.
Nihad TamimiPatient Reported Outcome Center of Excellence, Global Market Access, Primary Care Business Unit, Pfizer, Tadworth, United Kingdom.
Baylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient-reported outcome (PRO) measures that quantify disease impact have become important measures of outcome in COPD research and treatment. The objective of this literature review was to comprehensively evaluate psychometric properties of available PRO instruments and the ability of each of them to characterize pharmaceutical treatment effects from published clinical trial evidence. Identified in this study were several PRO measures, both those that have been used extensively in COPD clinical trials (St George's Respiratory Questionnaire and Chronic Respiratory Questionnaire) and new instruments whose full value is still to be determined. This suggests a great need for more information about the patient experience of treatment benefit, but this also may pose challenges to researchers, clinicians, and other important stakeholders (eg, regulatory agencies, pharmaceutical companies) who develop new treatment entities and payers (including but not limited to health technology assessment agencies such as the National Institute for Health and Care Excellence and the Canadian Agency for Drugs and Technologies in Health). The purpose of this review is to enable researchers and clinicians to gain a broad overview of PRO measures in COPD by summarizing the value and purpose of these measures and by providing sufficient detail for interested audiences to determine which instrument may be the most suitable for evaluating a particular research purpose.

Indexed as

Surveys and QuestionnairesHumansLungPredictive Value of TestsPsychometricsPulmonary Disease, Chronic ObstructiveQuality of LifeSeverity of Illness IndexTreatment OutcomeCOPDhealth related quality of lifepatient reported outcomepsychometric propertiesquality of life

Identifiers

PMID25897216
PMCPMC4396518
OpenAlexW2053368730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.