ArticleNucleic acids research2015
Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Advances in Epigenomic Sequencing and Their Applications in Cancer Diagnostics.Precision chemistry · 2025Review
- Single-cell omics: experimental workflow, data analyses and applications.Science China. Life sciences · 2025Review
- Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation.G3 (Bethesda, Md.) · 2024Article
- Reuniting philosophy and science to advance cancer research.Biological reviews of the Cambridge Philosophical Society · 2023Article
- scTEM-seq: Single-cell analysis of transposable element methylation to link global epigenetic heterogeneity with transcriptional programs.Scientific reports · 2022Article
- Pathways of DNA Demethylation.Advances in experimental medicine and biology · 2022Article
- Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.Advances in experimental medicine and biology · 2022Article
- DNA methylation studies in cattle.Journal of applied genetics · 2021Review
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Review
- The Relationship between the Methylation of Promoter Regions of Tumor Suppressor Genes PTEN and APC with Endometrial Cancer.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Mapping chromatin modifications at the single cell level.Development (Cambridge, England) · 2019Review
- Extensive exploration of T cell heterogeneity in cancers by single cell sequencing.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Power in Numbers: Single-Cell RNA-Seq Strategies to Dissect Complex Tissues.Annual review of genetics · 2018Review
- Analysis of DNA modifications in aging research.GeroScience · 2018Review
- Single-cell RNA sequencing to explore immune cell heterogeneity.Nature reviews. Immunology · 2018Review
- Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.Mutation research · 2017Review
- Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation.Stem cell reports · 2017Article
- Factors associated with aberrant imprint methylation and oligozoospermia.Scientific reports · 2017Article
- Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome.Genome biology · 2016Article
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Authors and funding
3 authors.
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Abstract
Stochastic epigenetic changes drive biological processes, such as development, aging and disease. Yet, epigenetic information is typically collected from millions of cells, thereby precluding a more precise understanding of cell-to-cell variability and the pathogenic history of epimutations. Here we present a novel procedure for directly detecting epimutations in DNA methylation patterns using single-cell, locus-specific bisulfite sequencing (SLBS). We show that within gene promoter regions of mouse hepatocytes the epimutation rate is two orders of magnitude higher than the mutation rate.
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