ArticleNucleic acids research2015
RBO Aleph: leveraging novel information sources for protein structure prediction.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- ResiRole: residue-level functional site predictions to gauge the accuracies of protein structure prediction techniques.Bioinformatics (Oxford, England) · 2021Article
- Improved Consensus-Fragment Selection in Template-Assisted Prediction of Protein Structures with the UNRES Force Field in CASP13.Journal of chemical information and modeling · 2020Article
- Sequential search leads to faster, more efficient fragment-based de novo protein structure prediction.Bioinformatics (Oxford, England) · 2018Article
- Continuous Automated Model EvaluatiOn (CAMEO) complementing the critical assessment of structure prediction in CASP12.Proteins · 2018Article
- EPSILON-CP: using deep learning to combine information from multiple sources for protein contact prediction.BMC bioinformatics · 2017Article
- Assessing Predicted Contacts for Building Protein Three-Dimensional Models.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Article
- CoinFold: a web server for protein contact prediction and contact-assisted protein folding.Nucleic acids research · 2016Article
- ORION: a web server for protein fold recognition and structure prediction using evolutionary hybrid profiles.Scientific reports · 2016Article
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Authors and funding
7 authors.
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Abstract
RBO Aleph is a novel protein structure prediction web server for template-based modeling, protein contact prediction and ab initio structure prediction. The server has a strong emphasis on modeling difficult protein targets for which templates cannot be detected. RBO Aleph's unique features are (i) the use of combined evolutionary and physicochemical information to perform residue-residue contact prediction and (ii) leveraging this contact information effectively in conformational space search. RBO Aleph emerged as one of the leading approaches to ab initio protein structure prediction and contact prediction during the most recent Critical Assessment of Protein Structure Prediction experiment (CASP11, 2014). In addition to RBO Aleph's main focus on ab initio modeling, the server also provides state-of-the-art template-based modeling services. Based on template availability, RBO Aleph switches automatically between template-based modeling and ab initio prediction based on the target protein sequence, facilitating use especially for non-expert users. The RBO Aleph web server offers a range of tools for visualization and data analysis, such as the visualization of predicted models, predicted contacts and the estimated prediction error along the model's backbone. The server is accessible at http://compbio.robotics.tu-berlin.de/rbo_aleph/.
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