ArticleThe American journal of tropical medicine and hygiene2015
Substandard antimalarials available in Afghanistan: a case for assessing the quality of drugs in resource poor settings.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Characterizing Medicine Quality by Active Pharmaceutical Ingredient Levels: A Systematic Review and Meta-Analysis across Low- and Middle-Income Countries.The American journal of tropical medicine and hygiene · 2022Pooled it
- Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.JAMA network open · 2018Pooled it
- Anti-malarial medicine quality field studies and surveys: a systematic review of screening technologies used and reporting of findings.Malaria journal · 2017Pooled it
- The availability of essential medicines in public healthcare facilities in Afghanistan: navigating sociopolitical and geographical challenges.Health policy and planning · 2025Article
- A Comprehensive Assessment of Quality of Antimalarial Medicines in Mainland Tanzania: Insights from Five Years of Postmarket Surveillance.The American journal of tropical medicine and hygiene · 2024Article
- Quality assessment of common anti-malarial medicines marketed in Gambella, National Regional State, South Western-Ethiopia.Malaria journal · 2024Article
- Knowledge, attitude, and practices toward malaria among hospital outpatients in Nangarhar, Afghanistan: A cross-sectional study.SAGE open medicine · 2024Article
- Prevalence of Poor Quality Ciprofloxacin and Metronidazole Tablets in Three Cities in Cameroon.The American journal of tropical medicine and hygiene · 2023Article
- Assessment of the Antimalarial Treatment Failure in Ebonyi State, Southeast Nigeria.Journal of xenobiotics · 2023Article
- Challenges of drug supply: How Afghanistan is struggling.Public health in practice (Oxford, England) · 2021Article
- Quality of selected anti-retroviral medicines: Tanzania Mainland market as a case study.BMC pharmacology & toxicology · 2021Article
- Sounding out falsified medicines from genuine medicines using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS).Scientific reports · 2021Article
- Levofloxacin: Insights Into Antibiotic Resistance and Product Quality.Frontiers in pharmacology · 2019Review
- Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?BMC public health · 2018Article
- Diagnostic Accuracy of Global Pharma Health Fund Minilab™ in Assessing Pharmacopoeial Quality of Antimicrobials.The American journal of tropical medicine and hygiene · 2018Article
- Examining the Quality of Medicines at Kenyan Healthcare Facilities: A Validation of an Alternative Post-Market Surveillance Model That Uses Standardized Patients.Drugs - real world outcomes · 2017Article
- Heterogeneous malaria transmission in long-term Afghan refugee populations: a cross-sectional study in five refugee camps in northern Pakistan.Malaria journal · 2016Article
- The global pandemic of falsified medicines: laboratory and field innovations and policy perspectives.The American journal of tropical medicine and hygiene · 2015Article
- Medicine quality in high-income countries: The obstacles to comparative prevalence studies.Medicine access @ point of careArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Good-quality antimalarials are crucial for the effective treatment and control of malaria. A total of 7,740 individual and packaged tablets, ampoules, and syrups were obtained from 60 randomly selected public (N = 35) and private outlets (N = 25) in Afghanistan. Of these, 134 samples were screened using the Global Pharma Health Fund (GPHF) MiniLab® in Kabul with 33/126 (26%) samples failing the MiniLab® disintegration test. The quality of a subsample (N = 37) of cholorquine, quinine, and sulfadoxine/pyrimethamine tablets was assessed by in vitro dissolution testing following U.S. Pharmacopeia (USP) monographs at a bioanalytical laboratory in London, United Kingdom. Overall, 12/32 (32%) samples of sulfadoxine/pyrimethamine and quinine were found not to comply with the USP tolerance limits. Substandard antimalarials were available in Afghanistan demonstrating that continuous monitoring of drug quality is warranted. However, in Afghanistan as in many low-income countries, capacity to determine and monitor drug quality using methods such as dissolution testing needs to be established to empower national authorities to take appropriate action in setting up legislation and regulation.
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