ArticleThe American journal of tropical medicine and hygiene2015
Integration of novel low-cost colorimetric, laser photometric, and visual fluorescent techniques for rapid identification of falsified medicines in resource-poor areas: application to artemether-lumefantrine.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Prevalence of Poor Quality Ciprofloxacin and Metronidazole Tablets in Three Cities in Cameroon.The American journal of tropical medicine and hygiene · 2023Article
- Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance.PloS one · 2023Article
- Article
- 3D-printed electrochemical pestle and mortar for identification of falsified pharmaceutical tablets.Mikrochimica acta · 2022Article
- Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method.Malaria journal · 2019Article
- Counterfeit and Substandard Test of the Antimalarial Tablet RiametMolecules (Basel, Switzerland) · 2019Article
- Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?BMC public health · 2018Article
- Field detection devices for screening the quality of medicines: a systematic review.BMJ global health · 2018Article
- The Evaluation of a Low-Cost Colorimeter for Glucose Detection in Salivary Samples.Sensors (Basel, Switzerland) · 2017Article
- Combating poor-quality anti-malarial medicines: a call to action.Malaria journal · 2016Review
- Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings.Tropical medicine and health · 2016Article
- Responding to the pandemic of falsified medicines.The American journal of tropical medicine and hygiene · 2015Article
- The global pandemic of falsified medicines: laboratory and field innovations and policy perspectives.The American journal of tropical medicine and hygiene · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The availability of falsified antimalarial drugs can be reduced with effective drug regulatory agencies and proper enforcement. Fundamental to these agencies taking action, rapid identification must be made as soon as they appear in the market place. Since falsified antimalarials occur mostly in developing countries, performing drug analysis presents itself with unique challenges. A fundamental factor in choosing a useful technique is affordability and simplicity. Therefore, we suggest a three-tiered drug evaluation strategy for identifying a falsified drug in resource-poor areas. Tier I is a simple comparison of a tablet's weight and dimensions with official specifications. Tier II uses inexpensive photometric devices (laser and fluorescence) to evaluate a tablet. Suspicious samples from Tier I and II assessments are then subjected to a colorimetric assay for active ingredients identification and quantification. In this article, we evaluate a novel colorimetric assay for the simultaneous assessment of both lumefantrine and artemether in co-formulated Coartem™ tablets, and integrate the method with two novel, low-cost, fluorescence and laser photometric devices. Image analysis software is used for the assessments. Although artemether-lumefantrine is used as an example, the strategy may be adapted to other medicines.
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Registered trials
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