ArticleThe American journal of tropical medicine and hygiene2015
Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Characterizing Medicine Quality by Active Pharmaceutical Ingredient Levels: A Systematic Review and Meta-Analysis across Low- and Middle-Income Countries.The American journal of tropical medicine and hygiene · 2022Pooled it
- Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.JAMA network open · 2018Pooled it
- Anti-malarial medicine quality field studies and surveys: a systematic review of screening technologies used and reporting of findings.Malaria journal · 2017Pooled it
- Assessing the quality of antimalarial drugs in Equatorial Guinea: a follow-up study.BMJ global health · 2025Article
- Prevalence and genetic diversity of polymorphisms inMalariaWorld journal · 2025Article
- Evaluation of portable devices for medicine quality screening: Lessons learnt, recommendations for implementation, and future priorities.PLoS medicine · 2021Article
- Novel anti-malarial drug strategies to prevent artemisinin partner drug resistance: A model-based analysis.PLoS computational biology · 2021Article
- Article
- Development of a lateral flow dipstick for simultaneous and semi-quantitative analysis of dihydroartemisinin and piperaquine in an artemisinin combination therapy.Drug testing and analysis · 2019Article
- Triboelectric Nanogenerator (TENG) Mass Spectrometry of Falsified Antimalarials.Rapid communications in mass spectrometry : RCM · 2018Article
- Are we doing enough to prevent poor-quality antimalarial medicines in the developing world?BMC public health · 2018Article
- Article
- Low Prevalence of Substandard and Falsified Antimalarial and Antibiotic Medicines in Public and Faith-Based Health Facilities of Southern Malawi.The American journal of tropical medicine and hygiene · 2017Article
- Examining the Quality of Medicines at Kenyan Healthcare Facilities: A Validation of an Alternative Post-Market Surveillance Model That Uses Standardized Patients.Drugs - real world outcomes · 2017Article
- Local constraints to access appropriate malaria treatment in the context of parasite resistance in Cambodia: a qualitative study.Malaria journal · 2017Article
- Prevalence of substandard and falsified artemisinin-based combination antimalarial medicines on Bioko Island, Equatorial Guinea.BMJ global health · 2017Article
- Rapid evaluation of artesunate quality with a specific monoclonal antibody-based lateral flow dipstick.Analytical and bioanalytical chemistry · 2016Article
- Combating poor-quality anti-malarial medicines: a call to action.Malaria journal · 2016Review
- Evidence of successful malaria case management policy implementation in Cambodia: results from national ACTwatch outlet surveys.Malaria journal · 2016Article
- Fake anti-malarials: start with the facts.Malaria journal · 2016Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study aimed to document the quality of artemisinin-containing antimalarials (ACAs) and to compare two methods of collecting antimalarials from drug outlets: through open surveyors and mystery clients (MCs). Few oral artemisinin-based monotherapies and no suspected falsified medicines were found. All 291 samples contained the stated active pharmaceutical ingredient (API) of which 69% were considered good quality by chemical analysis. Overall, medicine quality did not differ by collection method, although open surveyors were less likely to obtain oral artemisinin-based monotherapies than MCs. The results are an encouraging indication of the positive impact of the country's efforts to tackle falsified antimalarials and artemisinin-based monotherapies. However, poor-quality medicines remain an ongoing challenge that demands sustained political will and investment of human and financial resources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.