Evidence map›Paper›PMID 25896893›Full record

ReviewCritical care (London, England)2015

Neuroprotection in acute brain injury: an up-to-date review.

Nino Stocchetti, Fabio S Taccone, Giuseppe Citerio, Paul E Pepe, Peter D Le Roux, Mauro Oddo, Kees H Polderman, Robert D Stevens, William Barsan, Andrew I R Maas and 12 more

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04951453 (Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury), which is not on this map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04951453 completednot on this mapstarted 2021, after this paper: background citation

Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury

TypeobservationalSponsorRigshospitalet, DenmarkRan2021 to 2024Enrolled150ConditionsSubarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain InjuryArmsNone (observational)
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
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  11. Role of astrocytes connexins - pannexins in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Observational
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 6 countries.

Nino StocchettiDepartment of Physiopathology and Transplant, Milan University, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy. stocchet@policlinico.mi.it.
Fabio S TacconeDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxelles, 1070, Brussels, Belgium. ftaccone@ulb.ac.be.
Giuseppe CiterioDepartment of Health Science, University of Milan-Bicocca, Ospedale San Gerardo, Via Pergolesi 33, 20900, Monza, MB, Italy. g.citerio@hsgerardo.org.
Paul E PepeDepartment of Emergency Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8579, USA. Paul.Pepe@UTSouthwestern.edu.
Peter D Le RouxDepartment of Neurosurgery, Lankenau Medical Center, Wynnewood, PA, 19096, USA. LeRouxP@MLHS.ORG.
Mauro OddoDepartment of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanne, 1011, Lausanne, Switzerland. Mauro.Oddo@chuv.ch.
Kees H PoldermanDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. poldermankh@upmc.edu.
Robert D StevensDivision of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicine, Baltimore, MD, 21287, USA. rstevens@jhmi.edu.
William BarsanNETT Clinical Coordinating Center, University of Michigan, Ann Arbor, MI, 48106-0381, USA. wbarsan@med.umich.edu.
Andrew I R MaasDepartment of Neurosurgery, University Hospital Antwerp and University of Antwerp, 2650, Edegem, Belgium. andrew.maas@uza.be.
Geert MeyfroidtDepartment of Intensive Care, UZ Leuven, Campus Gasthuisberg, 3000, Leuven, Belgium. geert.meyfroidt@uzleuven.be.
Michael J BellDepartment of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. bellmj4@upmc.edu.
Robert SilbergleitNETT Clinical Coordinating Center, University of Michigan, Ann Arbor, MI, 48106-0381, USA. robie@med.umich.edu.
Paul M VespaDepartment of Neurocritical Care, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. PVespa@mednet.ucla.edu.
Alan I FadenCenter for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD, 21201, USA. afaden@anes.umm.edu.
Raimund HelbokDepartment of Neurology, Neurocritical Care Unit, Innsbruck Medical University, 6020, Innsbruck, Austria. raimund.helbok@uki.at.
Samuel TishermanDepartment of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. tishermansa@ccm.upmc.edu.
Elisa R ZanierIRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, 20156, Milan, Italy. elisa.zanier@marionegri.it.
Terence ValenzuelaDepartment of Emergency Medicine, University of Arizona, Tucson, AZ, 85724-5057, USA. hermanos.valenzuela@gmail.com.
Julia WendonInstitute of Liver Studies, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. julia.wendon@kcl.ac.uk.
David K MenonDivision of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. dkm13@wbic.cam.ac.uk.
Jean-Louis VincentDepartment of Intensive Care, Erasme Hospital, Université libre de Bruxelles, 1070, Brussels, Belgium. jlvincen@ulb.ac.be.
Université Libre de Bruxelles · BEUniversity of Maryland, Baltimore · USUniversity of Michigan–Ann Arbor · USUniversity of Pittsburgh Medical Center · USAddenbrooke's Hospital · GBFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITInnsbruck Medical University · ATJohns Hopkins University · USKing's College Hospital · GBLankenau Medical Center · USMario Negri Institute for Pharmacological Research · ITThe University of Texas Southwestern Medical Center · USUniversitair Ziekenhuis Leuven · BEUniversity of Antwerp · BEUniversity of Arizona · USUniversity of California, Los Angeles · USUniversity of Lausanne · CHUniversity of Milano-Bicocca · IT

Funding

Multiple Medical Therapies for Pediatric TBI; Comparative Effectiveness ApproachU01NS081041 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELL, MICHAEL J, WISNIEWSKI, STEPHEN R · 2013 to 2017
$15.9M
NINDS NIH HHS U01 NS081041
6 · The paper itself

Abstract

Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

Indexed as

NeuroprotectionBrain InjuriesBrain IschemiaHumansNeuroprotective AgentsStrokeNeuroprotective Agents

Identifiers

PMID25896893
PMCPMC4404577
OpenAlexW2127326606

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.