Evidence map›Paper›PMID 25896700›Full record

ArticleAntimicrobial agents and chemotherapy2015

Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Musang Liu, Rong Zeng, Lili Zhang, Dongmei Li, Guixia Lv, Yongnian Shen, Hailin Zheng, Qiangqiang Zhang, Jingjun Zhao, Nan Zheng and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Antifungal Susceptibility andMicroorganisms · 2026
    Article
  2. Rare Case ofInternational medical case reports journal · 2025
    Article
  3. Article
  4. Antifungal Susceptibility and Genotypic Analysis ofInfection and drug resistance · 2024
    Article
  5. Article
  6. Article
  7. Azole Resistance andJournal of fungi (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Studies in mycology · 2021
    Review
  11. Article
  12. Article
  13. The CAntimicrobial agents and chemotherapy · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Detecting Azole-Antifungal Resistance inJournal of fungi (Basel, Switzerland) · 2020
    Review
  19. Infection and drug resistance · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Musang LiuDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Rong ZengDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Lili ZhangDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Dongmei LiDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China Georgetown University Medical Center, Department of Microbiology and Immunology, Washington, DC, USA.
Guixia LvDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Yongnian ShenDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Hailin ZhengDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Qiangqiang ZhangDermatology Department, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Jingjun ZhaoDermatology Department, Tongji Hospital, Tongji University, Shanghai, People's Republic of China.
Nan ZhengMedical School, Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Weida LiuDepartment of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China liumyco@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.

Indexed as

Antifungal AgentsAspergillosisAspergillus fumigatusAzolesChinaCytochrome P-450 Enzyme SystemDrug Resistance, FungalFungal ProteinsGenotypeHumansItraconazoleMicrobial Sensitivity TestsMolecular Sequence DataMutationAntifungal AgentsAzolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsItraconazole

Identifiers

PMID25896700
PMCPMC4468671

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.