ReviewHeart failure reviews2015
Structural brain alterations in heart failure: a review of the literature and implications for risk of Alzheimer's disease.
Review in Heart failure reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Clinical and Imaging Markers of Cardiac Function and Brain Health: A Meta-Analysis of Community-Based Studies.Neurology · 2025Pooled it
- Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure.Journal of cardiac failure · 2022Trial
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
- Lower cardiac output is a risk factor for faster cerebral atrophy over a 11-year follow-up period in APOE-ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Alterations of Cerebral Extracellular Vesicle microRNA Profiling Potentially Disrupts Brain Homeostasis Following Myocardial Infarction.Biomolecules · 2026Article
- Contents under pressure: vascular proliferation and gliosis in the brains of Cavalier King Charles Spaniels with syringomyelia.Frontiers in veterinary science · 2026Article
- Multimodal MRI to elucidate cross-organ coupling mechanisms of the heart-brain axis.Frontiers in cardiovascular medicine · 2026Review
- Neurostructural Correlates of Polygenic Risk for Coronary Artery Disease in Relation to Youth Bipolar Disorder.Bipolar disorders · 2025Article
- Brain Aging in Patients With Cardiovascular Disease From the UK Biobank.Human brain mapping · 2025Article
- Cardiovascular-kidney-metabolic syndrome and incidence of dementia among older adults.The journal of prevention of Alzheimer's disease · 2025Article
- Loss of glymphatic homeostasis in heart failure.Brain : a journal of neurology · 2025Article
- Alterations in the inflammatory homeostasis of aging-related cardiac dysfunction and Alzheimer's diseases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Biological heart and brain ageing in subjects with cardiovascular diseases.Frontiers in cardiovascular medicine · 2025Article
- The Impact of HeartMate3 Speed Titration on Cerebral Hemodynamics.Journal of cardiac failure · 2024Article
- Volumetric brain MRI signatures of heart failure with preserved ejection fraction in the setting of dementia.Magnetic resonance imaging · 2024Article
- The role of vitamin K2 in cognitive impairment: linking vascular health to brain health.Frontiers in aging neuroscience · 2024Review
- Exercise-induced reductions in central command network cerebral blood flow assessed with arterial spin labeling MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Heart failure causally affects the brain cortical structure: a Mendelian randomization study.Frontiers in neuroscience · 2024Article
- Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiovascular disease is a recognized contributor to the pathogenesis of Alzheimer's disease (AD). Heart failure (HF) is a cardiovascular subtype that can be used to model the contribution of cardiovascular disease to AD. Neuroimaging research indicates that HF patients exhibit a diverse range of structural brain alterations and epidemiological studies suggest HF may be an important risk factor for AD. The neural alterations observed in HF may overlap with those observed in AD and contribute to increased risk of AD in HF patients. To examine this possibility, we reviewed structural MRI studies in persons with HF. We examined subcortical brain regions affected in the early stages of AD (medial temporal lobes), as well as cortical alterations that typically occur in the later stages of AD. Our review indicates that patients with HF exhibit greater neural atrophy and white matter microstructural alterations of nearly every region of the Papez circuit (e.g., hippocampus, cingulate gyrus, thalamus, mammillary bodies, and fornix), as well-significant alterations in cortical and cerebellar regions. Based on animal research and past work in AD patients, the mechanisms for structural brain changes in HF may stem from reductions in cerebral blood flow subsequent to cardiac deficiency. This review supports the hypothesis that HF may contribute to AD risk via widespread structural brain changes, including many of the same regions affected by AD. Case-controlled prospective neuroimaging studies with long-term follow-ups are needed to clarify the risk of AD in HF and elucidate the neural underpinnings of AD risk in HF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.