ArticleNature communications2015
Combinatorial code governing cellular responses to complex stimuli.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Processing stimulus dynamics by the NF-κB network in single cells.Experimental & molecular medicine · 2023Review
- A systematic evaluation of the computational tools for ligand-receptor-based cell-cell interaction inference.Briefings in functional genomics · 2022Article
- THOR's Hammer: the Antibiotic Koreenceine Drives Gene Expression in a Model Microbial Community.mBio · 2022Article
- Fabrication of Metal-Insulator-Metal Nanostructures Composed of Au-MgFMicromachines · 2022Article
- A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells.Cell discovery · 2022Article
- Human Conventional and Plasmacytoid Dendritic Cells Differ in Their Ability to Respond toFrontiers in immunology · 2022Article
- Dissection of intercellular communication using the transcriptome-based framework ICELLNET.Nature communications · 2021Article
- Determinants of Ligand Specificity and Functional Plasticity in Type I Interferon Signaling.Frontiers in immunology · 2021Article
- Article
- Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations.Cell systems · 2020Article
- Resiquimod-Mediated Activation of Plasmacytoid Dendritic Cells Is Amplified in Multiple Sclerosis.International journal of molecular sciences · 2019Article
- Cytokine-mediated communication: a quantitative appraisal of immune complexity.Nature reviews. Immunology · 2019Review
- The Medicinal Plant PairFrontiers in pharmacology · 2019Article
- Article
- Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity.Frontiers in immunology · 2017Article
- High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells.Cell chemical biology · 2016Article
- The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Cells adapt to their environment through the integration of complex signals. Multiple signals can induce synergistic or antagonistic interactions, currently considered as homogenous behaviours. Here, we use a systematic theoretical approach to enumerate the possible interaction profiles for outputs measured in the conditions 0 (control), signals X, Y, X+Y. Combinatorial analysis reveals 82 possible interaction profiles, which we biologically and mathematically grouped into five positive and five negative interaction modes. To experimentally validate their use in living cells, we apply an original computational workflow to transcriptomics data of innate immune cells integrating physiopathological signal combinations. Up to 9 of the 10 defined modes coexisted in context-dependent proportions. Each interaction mode was preferentially used in specific biological pathways, suggesting a functional role in the adaptation to multiple signals. Our work defines an exhaustive map of interaction modes for cells integrating pairs of physiopathological and pharmacological stimuli.
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