Trial reportAmerican journal of ophthalmology2015
Choroidal Thickness Profiles in Myopic Eyes of Young Adults in the Correction of Myopia Evaluation Trial Cohort.
Trial report in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527274 (Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Defocus in Soft Contact Lenses on Internal Retinal Vascularization
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020Pooled it
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- Associations Between Choroidal Structural Parameters and Cone Photoreceptors in Young High Myopia.Translational vision science & technology · 2026Article
- Age- and Myopia-Related 3-Dimensional Remodeling of Choroidal Thickness in Children.Ophthalmology science · 2026Article
- Interaction Between Near Work and Narrowband Light on Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- Relationship between choroidal thickness changes and macrophage polarization in high myopia.Frontiers in medicine · 2026Review
- RLRL Therapeutic Feasibility and Potential Mechanism on Myopia.International journal of molecular sciences · 2025Review
- Three-dimensional choroidal parameter differences in myopic anisometropia.BMC ophthalmology · 2025Article
- Repeatability, reproducibility, and agreement for three optical coherence tomography instruments.BMC ophthalmology · 2025Article
- Choroidal thickness in macular, nasal midperiphery, and temporal midperiphery regions and its relationship with axial length and refractive error.Japanese journal of ophthalmology · 2025Observational
- Subclinical Microvascular Deficits as a Promising Biomarker for Functional Impairment in Non-Pathological High Myopia: A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Investigation of choroidal vascular alterations in eyes with myopia using ultrawidefield optical coherence tomography angiography.BMJ open ophthalmology · 2024Article
- Evaluation of retinal and choroidal microvascular alteration after ICL V4c implantation based on OCTA.BMC ophthalmology · 2024Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression.BMJ open ophthalmology · 2024Article
- Topical Application of Bunazosin Hydrochloride Suppresses Myopia Progression With an Increase in Choroidal Blood Perfusion.Investigative ophthalmology & visual science · 2023Article
- Changes in Refractive Error During Young Adulthood: The Effects of Longitudinal Screen Time, Ocular Sun Exposure, and Genetic Predisposition.Investigative ophthalmology & visual science · 2023Article
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeTo examine the relationship of choroidal thickness with axial length (AL) and myopia in young adult eyes in the ethnically diverse Correction of Myopia Evaluation Trial (COMET) cohort.
designCross-sectional, multicenter study.
methodsIn addition to measures of myopia by cycloplegic autorefraction and AL by A-scan ultrasonography, participants underwent optical coherence tomography imaging of the choroid in both eyes at their last visit (14 years after baseline). Using digital calipers, 2 independent readers measured choroidal thickness in the right eye (left eye if poor quality; n = 37) at 7 locations: fovea and 750, 1500, and 2250 μm nasal (N) and temporal (T) to the fovea.
resultsChoroidal thickness measurements were available from 294 of 346 (85%) imaged participants (mean age: 24.3 ± 1.4 years; 44.9% male) with mean myopia of -5.3 ± 2.0 diopters and mean AL of 25.5 ± 1.0 mm. Overall, choroidal thickness varied by location (P < .0001) and was thickest at the fovea (273.8 ± 70.9 μm) and thinnest nasally (N2250, 191.5 ± 69.3 μm). Multivariable analyses showed significantly thinner choroids in eyes with more myopia and longer AL at all locations except T2250 (P ≤ .001) and presence of peripapillary crescent at all locations except T1500 and T2250 (P ≤ .0001). Choroidal thickness varied by ethnicity at N2250 (P < .0001), with Asians having the thinnest and African Americans the thickest choroids.
conclusionChoroids are thinner in longer, more myopic young adult eyes. The thinning was most prominent nasally and in eyes with a crescent. In the furthest nasal location, ethnicity was associated with choroidal thickness. The findings suggest that choroidal thickness should be evaluated, especially in the nasal regions where myopic degenerations are most commonly seen clinically.
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