Evidence map›Paper›PMID 25896388›Full record

ReviewBiochimica et biophysica acta2015

Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP.

Angad P Mehta, Sameh H Abdelwahed, Tadhg P Begley

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Guiding covalent catalysis enables a carbon-inserting rearrangement in molybdenum cofactor biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Structural studies of viperin, an antiviral radical SAM enzyme.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Angad P MehtaDepartment of Chemistry, Texas A&M University, College Station, TX 77843, United States.
Sameh H AbdelwahedDepartment of Chemistry, Texas A&M University, College Station, TX 77843, United States; Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
Tadhg P BegleyDepartment of Chemistry, Texas A&M University, College Station, TX 77843, United States. Electronic address: begley@chem.tamu.edu.

Funding

The mechanistic enzymology of thiamin biosynthesisR37DK044083 · NIDDK · TEXAS A&M UNIVERSITY · PI BEGLEY, TADHG P. · 2008 to 2017
$3.7M
NIDDK NIH HHS R37 DK044083
6 · The paper itself

Abstract

The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2' and C3' carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.

Indexed as

BiocatalysisCarbonCoenzymesEscherichia coli ProteinsGuanosine TriphosphateHumansIsomerasesMetalloproteinsMolybdenum CofactorsPteridinesPurinesRiboseCarbonCoenzymesEscherichia coli ProteinsGuanosine TriphosphateIsomerasesMetalloproteinsMoaA protein, E coliMolybdenum CofactorsmolybdopterinPteridinespurinePurinesRiboseIntermediate trappingMechanismMoaAMolybtopterinSubstrate analog

Identifiers

PMID25896388
PMCPMC4506844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.