ArticleNature2015
A multilevel multimodal circuit enhances action selection in Drosophila.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers, 1 of them a synthesis that pooled it.
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Who cites it
264 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A connectome and analysis of the adulteLife · 2020Pooled it
- Region-specific mechanosensation modulateseLife · 2026Article
- Real-time, cross-modal genotype mapping of free-movingScience advances · 2026Article
- The motor pattern of rolling escape locomotion in Drosophila larvae.The Journal of experimental biology · 2026Article
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- A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae.PLoS genetics · 2026Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- A new system for studying neuronal remodeling and its relation to behavior in Drosophila.Communications biology · 2025Article
- Neurexin regulates mechanical nociceptive sensitization by central inhibition inScience advances · 2025Article
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- Using comparative connectomics to understand variability and evolution in neural circuits.Nature methods · 2025Article
- Prediction of neural activity in connectome-constrained recurrent networks.Nature neuroscience · 2025Article
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Article
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Many faces of neuronal activity manipulation in Drosophila.Neural regeneration research · 2025Article
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- Article
- Article
204 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
Natural events present multiple types of sensory cues, each detected by a specialized sensory modality. Combining information from several modalities is essential for the selection of appropriate actions. Key to understanding multimodal computations is determining the structural patterns of multimodal convergence and how these patterns contribute to behaviour. Modalities could converge early, late or at multiple levels in the sensory processing hierarchy. Here we show that combining mechanosensory and nociceptive cues synergistically enhances the selection of the fastest mode of escape locomotion in Drosophila larvae. In an electron microscopy volume that spans the entire insect nervous system, we reconstructed the multisensory circuit supporting the synergy, spanning multiple levels of the sensory processing hierarchy. The wiring diagram revealed a complex multilevel multimodal convergence architecture. Using behavioural and physiological studies, we identified functionally connected circuit nodes that trigger the fastest locomotor mode, and others that facilitate it, and we provide evidence that multiple levels of multimodal integration contribute to escape mode selection. We propose that the multilevel multimodal convergence architecture may be a general feature of multisensory circuits enabling complex input-output functions and selective tuning to ecologically relevant combinations of cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.