Evidence map›Paper›PMID 25896309›Full record

ArticleAmerican journal of nephrology2015

Gout after living kidney donation: correlations with demographic traits and renal complications.

Ngan N Lam, Amit X Garg, Dorry L Segev, Mark A Schnitzler, Huiling Xiao, David Axelrod, Daniel C Brennan, Bertram L Kasiske, Janet E Tuttle-Newhall, Krista L Lentine

Open access · bronzeAbstract read
In one paragraph

Article in American journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Pooled it
  2. Guideline
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  6. Article
  7. Review
  8. Article
  9. Review
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  11. Article
  12. Follow-up Care of Living Kidney Donors in Alberta, Canada.Canadian journal of kidney health and disease · 2018
    Article
  13. Validation of Living Donor Nephrectomy Codes.Canadian journal of kidney health and disease · 2018
    Article
  14. Review
  15. The 3-Year Incidence of Gout in Elderly Patients with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2017
    Article
  16. Predonation Prescription Opioid Use: A Novel Risk Factor for Readmission After Living Kidney Donation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Ngan N LamDivision of Nephrology, Western University, London, Ont., Canada.
Amit X Garg
Dorry L Segev
Mark A Schnitzler
Huiling Xiao
David Axelrod
Daniel C Brennan
Bertram L Kasiske
Janet E Tuttle-Newhall
Krista L Lentine
UCLouvain Saint-Louis Brussels · BEWestern University · CADartmouth College · USHennepin County Medical Center · USJohns Hopkins University · USWashington University in St. Louis · US

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
NIDDK NIH HHS K24 DK101828NIDDK NIH HHS K24-DK101828NIDDK NIH HHS R01 DK096008NIDDK NIH HHS R01-DK096008
6 · The paper itself

Abstract

backgroundThe demographic and clinical correlates of gout after living kidney donation are not well described.

methodsUsing a unique database that integrates national registry identifiers of U.S. living kidney donors (1987-2007) with billing claims from a private health insurer (2000-2007), we identified post-donation gout based on medical diagnosis codes or pharmacy fills for gout therapies. The frequencies and demographic correlates of gout after donation were estimated by Cox regression with left- and right-censoring. We also compared the rates of renal diagnoses among donors with and without gout, matched in the ratio 1:3 by age, sex, and race.

resultsThe study sample of 4,650 donors included 13.1% African Americans. By seven years, African Americans were almost twice as likely to develop gout as Caucasian donors (4.4 vs. 2.4%; adjusted hazard ratio, aHR, 1.8; 95% confidence interval (CI) 1.0-3.2). Post-donation gout risk also increased with older age at donation (aHR per year 1.05) and was higher in men (aHR 2.80). Gout rates were similar in donors and age- and sex-matched general non-donors (rate ratio 0.86; 95% CI 0.66-1.13). Compared to matched donors without gout, donors with gout had more frequent renal diagnoses, reaching significance for acute kidney failure (rate ratio 12.5; 95% CI 1.5-107.0), chronic kidney disease (rate ratio 5.0; 95% CI 2.1-11.7), and other disorders of the kidney (rate ratio 2.2; 95% CI 1.2-4.2).

conclusionDonor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after demographic adjustment.

Indexed as

AdultAge FactorsBlack or African AmericanFemaleGoutHumansIncidenceKidney DiseasesKidney TransplantationLiving DonorsMaleMiddle AgedNephrectomyRegistriesRisk FactorsSex Factors

Identifiers

PMID25896309
PMCPMC4522163
OpenAlexW2020388350

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.