ArticleCancer prevention research (Philadelphia, Pa.)2015
The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry.
Article in Cancer prevention research (Philadelphia, Pa.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Association between tonsillectomy and risk of oropharyngeal cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Pooled it
- Association between tonsillectomy and oropharyngeal cancer risk: a retrospective cohort study.Oral and maxillofacial surgery · 2024Article
- Association of Human Papillomavirus Infection with Tonsillar Cancers: A Systematic Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Cancer risk following surgical removal of tonsils and adenoids - a population-based, sibling-controlled cohort study in Sweden.BMC medicine · 2023Article
- Synchronous tonsillar tumors with differing histopathology: A case report and review of the literature.Cancer reports (Hoboken, N.J.) · 2022Review
- Childhood tonsillectomy alters the primary distribution of HPV-related oropharyngeal squamous cell carcinoma.Laryngoscope investigative otolaryngology · 2020Article
- The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease.Frontiers in immunology · 2020Review
- Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma.PloS one · 2020Article
- Observational
- Kinetics of the Human Papillomavirus Type 16 E6 Antibody Response Prior to Oropharyngeal Cancer.Journal of the National Cancer Institute · 2017Article
- Synchronous bilateral tonsil carcinoma: case presentation and review of the literature.Infectious agents and cancer · 2017Review
- Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy.PloS one · 2017Article
- HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.Cancer research · 2016Article
- Current Role of Surgery in the Management of Oropharyngeal Cancer.Journal of oncology practice · 2016Review
- Human papillomavirus and head and neck carcinomas: focus on evidence in the babel of published data.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2016Review
- Tonsillectomy and Incidence of Oropharyngeal Cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Previous tonsillectomy modifies odds of tonsil and base of tongue cancer.British journal of cancer · 2016Article
- Transforming Cancer Prevention through Precision Medicine and Immune-oncology.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Review
- Tonsillectomy and Risk of Oropharyngeal Cancer: Implications for Research and Prevention.Cancer prevention research (Philadelphia, Pa.) · 2015Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The incidence of oropharyngeal carcinoma, involving palatine and lingual tonsils, is increasing globally. This significant rise is driven by human papillomavirus. Whether palatine tonsillectomy affects risk of diagnosis with oropharyngeal carcinoma is unknown. The association between tonsillectomy and incidence of oropharyngeal carcinoma was explored in the Danish Cancer Registry. The association between tonsillectomy and oropharyngeal carcinoma was analyzed by time since first registration of tonsillectomy. Tonsillectomy was a time-dependent variable. Individuals were censored for death, emigration, or tonsillectomy within incident year of diagnosis. Incidence rate ratios (RR) were estimated by Poisson regression models and adjusted for confounders. Kaplan-Meier survival analyses were compared by the log-rank test, and HRs were estimated by Cox proportional hazards models. From 1977 to 2012, the incidence of tonsillectomies significantly decreased, whereas the incidence of oropharyngeal carcinoma significantly increased. Tonsillectomy was not associated with risk of oropharyngeal carcinoma or malignancies of other anatomic sites, including base of tongue. However, tonsillectomy significantly reduced risk of diagnosis with tonsil carcinoma [RR, 0.40; 95% confidence interval (CI), 0.22-0.70]. The risk of diagnosis with tonsil carcinoma at age <60 years was significantly decreased (RRadj, 0.15; 95% CI, 0.06-0.41) after tonsillectomy. Tonsillectomy within 1 year of diagnosis with tonsil carcinoma was associated with significantly improved overall survival (HR, 0.53; 95% CI, 0.38-0.74). In conclusion, remote history of tonsillectomy reduces the risk of diagnosis with tonsil carcinoma. These data inform risk and benefit of tonsillectomy, a common procedure and design of secondary prevention trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.