Evidence map›Paper›PMID 25896182›Full record

Trial reportNutrition journal2015

Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study.

Yuka Kawakami, Hisami Yamanaka-Okumura, Yuko Naniwa-Kuroki, Masae Sakuma, Yutaka Taketani, Eiji Takeda

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  9. Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review.International journal of environmental research and public health · 2023
    Review
  10. Review
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  12. Review
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  14. Flaxseed and Its Components in Treatment of Hyperlipidemia and Cardiovascular Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2020
    Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuka KawakamiDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. k.yuka0630@gmail.com.
Hisami Yamanaka-OkumuraDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. okumurah@tokushima-u.ac.jp.
Yuko Naniwa-KurokiDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. kuroki@town.kotoura.tottori.jp.
Masae SakumaDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. sakuma@u-shizuoka-ken.ac.jp.
Yutaka TaketaniDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. taketani@tokushima-u.ac.jp.
Eiji TakedaDepartment of Clinical Nutrition and Food Management, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. takeda.eiji@tokushima-u.ac.jp.
Tokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effects of alpha-linolenic acid (ALA) on cardiovascular risk factors considerably vary between published reports. Therefore, we investigated the effects of 12-week supplementation with flaxseed oil (FO), which is a rich source of ALA, on cardiovascular risk factors such as serum small dense low-density lipoprotein (sd-LDL) concentrations.

methodsIn a randomized, double blind, crossover study, 15 subjects ingested 10 g of FO or corn oil (CO), containing 5.49 g and 0.09 g of ALA, respectively, once daily with dinner. Blood samples were collected at 0, 4 and 12 weeks, and were used for analysis of serum lipid, lipid-related proteins, serum fatty acids and serum sd-LDL cholesterol. Differences during the test period were identified using a repeated-measures analysis of variance (ANOVA) for within-group effects. Group differences were identified using paired t-test at each blood sampling time point.

resultsALA and eicosapentaenoic acid concentrations were significantly higher in the FO period at 4 and 12 weeks than in the CO period. No significant differences in docosahexaenoic acid concentrations were observed between two periods, and cholesteryl ester transfer protein and apolipoprotein B concentrations were significantly lower in the FO period than in the CO period at 12 weeks. FO supplementation was associated with a significant decrease in sd-LDL concentrations at 4 and 12 weeks, and CO supplementation had no effect. Moreover, sd-LDL concentrations were significantly lower in the FO period than in the CO period at 4 weeks. Among subjects with triglyceride (TG) concentrations of >100 mg/dl, FO supplementation markedly reduced sd-LDL concentrations at 4 and 12 weeks compared with baseline. Sd-LDL concentrations significantly differed between the periods at both 4 and 12 weeks.

conclusionThis study indicates that the FO, which is a rich source of ALA, leads to lower sd-LDL cholesterol concentrations.

Indexed as

Adultalpha-Linolenic AcidAnalysis of VarianceApolipoproteins BCholesterol Ester Transfer ProteinsCorn OilCross-Over StudiesDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidHumansJapanLinseed OilLipoproteins, LDLMaleMiddle Agedalpha-Linolenic AcidApolipoproteins BCholesterol Ester Transfer ProteinsCorn OilDocosahexaenoic AcidsEicosapentaenoic AcidLinseed OilLipoproteins, LDLTriglycerides

Identifiers

PMID25896182
PMCPMC4409715
OpenAlexW2075695527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.