Evidence map›Paper›PMID 25896098›Full record

ReviewAlcohol (Fayetteville, N.Y.)2015

Applying the new genomics to alcohol dependence.

Sean P Farris, Andrzej Z Pietrzykowski, Michael F Miles, Megan A O'Brien, Pietro P Sanna, Samir Zakhari, R Dayne Mayfield, R Adron Harris

Abstract readReview
In one paragraph

Review in Alcohol (Fayetteville, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Genes and Alcohol Consumption: Studies with Mutant Mice.International review of neurobiology · 2016
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Sean P FarrisWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.
Andrzej Z PietrzykowskiDepartment of Animal Sciences, Rutgers University, New Brunswick, NJ, USA; Department of Genetics, Rutgers University, New Brunswick, NJ, USA.
Michael F MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Megan A O'BrienDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Pietro P SannaMolecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, CA, USA.
Samir ZakhariOffice of Science, Distilled Spirits Council of the United States, Washington, DC, USA.
R Dayne MayfieldWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.
R Adron HarrisWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA. Electronic address: harris@austin.utexas.edu.
The University of Texas at Austin · USVirginia Commonwealth University · USOffice of Science · USRutgers, The State University of New Jersey · USScripps Research Institute · US

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAMID I AKBARALI · 2014 to 2026
$13.8M
Integrative Neuroscience Initiative on Alcoholism - West - SupplementU01AA013517 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2001 to 2014
$12.7M
GENE EXPRESSION IN THE HUMAN ALCOHOLIC BRAINR01AA012404 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI MAYFIELD, ROY DAYNE · 2000 to 2025
$10.7M
INIA: ANIMAL COREU01AA013520 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI YURI A BLEDNOV, ROBERT O. MESSING · 2001 to 2026
$9.5M
Neurochemical & Behavioral Correlates of ETOH EffectsT32AA007471 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI Kimberly Nixon · 1987 to 2026
$9.2M
Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
Next Generation Sequencing of Human Alcoholic BrainU01AA020926 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Roy DAYNE MAYFIELD · 2011 to 2026
$6.7M
Gene Network Perturbations in Alcohol Dependence - A Systems BiologyApproachR01AA021667 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2013 to 2026
$6.1M
Novel molecular and cellular approaches for alcoholism medication developmentP01AA020683 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI BLEDNOV, YURI A · 2012 to 2016
$3.3M
Of Mice and Primates: Gene Networks in Excessive Ethanol Consumption and AnxietyU01AA016667 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MILES, MICHAEL F · 2007 to 2016
$2.4M
BRAIN TISSUE RESOURCE CENTER FOR ALCOHOL RESEARCHR24AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI KRIL, JILLIAN JUNE · 2000 to 2011
$2.2M
Project 3: Cross Species Characterization of Gene Networks in Acute ResponsesP20AA017828 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, MILES, MICHAEL F · 2009 to 2012
$2.2M
NIAAA NIH HHS AA012404NIAAA NIH HHS AA013517NIAAA NIH HHS AA017481NIAAA NIH HHS AA017581NIAAA NIH HHS AA017920NIAAA NIH HHS AA020960NIAAA NIH HHS AA021667NIAAA NIH HHS F31 AA021035NIAAA NIH HHS F31AA021035NIAAA NIH HHS K08 AA017481NIAAA NIH HHS P01 AA020683NIAAA NIH HHS P20 AA017828NIAAA NIH HHS P20AA017828NIAAA NIH HHS R01 AA012404NIAAA NIH HHS R01 AA017920NIAAA NIH HHS R01 AA021667NIAAA NIH HHS R13 AA017581NIAAA NIH HHS R24 AA012725NIAAA NIH HHS R28 AA012725NIAAA NIH HHS RC2 AA019382NIAAA NIH HHS RC2AA019382NIAAA NIH HHS T32 AA007471NIAAA NIH HHS U01 AA013517NIAAA NIH HHS U01 AA013520NIAAA NIH HHS U01AA013520NIAAA NIH HHS U01 AA016667NIAAA NIH HHS U01AA016667NIAAA NIH HHS U01 AA020926NIAAA NIH HHS U01AA020926NIAAA NIH HHS U01 AA020960NIDA NIH HHS P30 DA033934
6 · The paper itself

Abstract

This review summarizes the proceedings of a symposium presented at the "Alcoholism and Stress: A Framework for Future Treatment Strategies" conference held in Volterra, Italy on May 6-9, 2014. The overall goal of the symposium titled "Applying the New Genomics to Alcohol Dependence", chaired by Dr. Adron Harris, was to highlight recent genomic discoveries and applications for profiling alcohol use disorder (AUD). Dr. Sean Farris discussed the gene expression networks related to lifetime consumption of alcohol within human prefrontal cortex. Dr. Andrzej Pietrzykowski presented the effects of alcohol on microRNAs in humans and animal models. Alcohol-induced alterations in the synaptic transcriptome were discussed by Dr. Michael Miles. Dr. Pietro Sanna examined methods to probe the gene regulatory networks that drive excessive alcohol drinking, and Dr. Samir Zakhari served as a panel discussant and summarized the proceedings. Collectively, the presentations emphasized the power of integrating multiple levels of genetics and transcriptomics with convergent biological processes and phenotypic behaviors to determine causal factors of AUD. The combined use of diverse data types demonstrates how unique approaches and applications can help categorize genetic complexities into relevant biological networks using a systems-level model of disease.

Indexed as

Gene Expression RegulationAlcoholismAnimalsEpigenesis, GeneticGene Expression ProfilingGene Regulatory NetworksGenomicsHumansMicroRNAsSequence Analysis, RNATranscriptomeMicroRNAsEpigeneticsGene expression networksmicroRNAsRNA-SeqSynaptic transcriptomeSystems biology

Identifiers

PMID25896098
PMCPMC4586299
OpenAlexW1994197277

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.