ReviewBiological psychiatry2015
Excitation-inhibition discoordination in rodent models of mental disorders.
Review in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Computational modeling reveals cognitive processes in simple rodent depression tests.Cell reports methods · 2025Article
- Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome.Biology · 2025Review
- GABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation.Biological psychiatry global open science · 2024Article
- A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields.Cell reports · 2023Article
- The efficacy of non-invasive brain stimulation in the treatment of children and adolescents with Anorexia Nervosa: study protocol of a randomized, double blind, placebo-controlled trial.Journal of eating disorders · 2023Article
- Deep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes.BMC psychiatry · 2023Article
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Etiopathogenic Models of Psychosis Spectrum Illnesses Must Resolve Four Key Features.Biological psychiatry · 2022Review
- Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus.Behavioral neuroscience · 2020Article
- Optogenetic "low-theta" pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand.Hippocampus · 2020Article
- Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Synaptic plasticity/dysplasticity, process memory and item memory in rodent models of mental dysfunction.Schizophrenia research · 2019Review
- Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior.Frontiers in molecular neuroscience · 2019Article
- Normal CA1 Place Fields but Discoordinated Network Discharge in a Fmr1-Null Mouse Model of Fragile X Syndrome.Neuron · 2018Article
- Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?Epilepsy & behavior : E&B · 2018Review
- Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1.PLoS biology · 2018Article
- Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts that failures of neural coordination cause cognitive deficits in the judicious processing and use of information. Abnormal dynamic coordination of excitatory and inhibitory neural discharge in pharmacologic and genetic rodent models supports the discoordination hypothesis. These observations suggest excitation-inhibition discoordination and aberrant neural circuit dynamics as causes of cognitive impairment, as well as therapeutic targets for cognition-promoting treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.