ArticlePediatric surgery international2015
Usefulness of Wieneke criteria in assessing morphologic characteristics of adrenocortical tumors in children.
Article in Pediatric surgery international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Prognostic Significance of Major Histocompatibility Complex Class II Expression in Pediatric Adrenocortical Tumors: A St. Jude and Children's Oncology Group Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Trial
- Pediatric Adrenocortical Carcinoma: The Nuts and Bolts of Diagnosis and Treatment and Avenues for Future Discovery.Cancer management and research · 2024Review
- Peripheral precocious puberty in Li-Fraumeni syndrome: a case report and literature review of pure androgen-secreting adrenocortical tumors.Journal of medical case reports · 2023Review
- Article
- Pathological and Genetic Stratification for Management of Adrenocortical Carcinoma.The Journal of clinical endocrinology and metabolism · 2022Review
- Histopathological Criteria for Paediatric Adrenocortical Carcinoma.Hormone research in paediatrics · 2022Article
- Adrenocortical adenoma manifesting as Cushing's syndrome and pseudo-precocious puberty in a toddler.Pediatric endocrinology, diabetes, and metabolism · 2022Article
- Review
- The Role of Biomarkers in Adrenocortical Carcinoma: A Review of Current Evidence and Future Perspectives.Biomedicines · 2021Review
- Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging.Biomedicines · 2021Review
- Revisiting the role of the pathological grading in pediatric adrenal cortical tumors: results from a national cohort study with pathological review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior.Oncotarget · 2017Article
- Management and prognosis of adrenocortical tumors in children: can we find out an appropriate points-scoring system to predict prognosis?Pediatric surgery international · 2017Article
- Adrenocortical Neoplasms in Children: Treatment and Outcomes.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdrenocortical tumors (ACT) occur rarely in pediatric age group. Pediatric ACTs behave differently from their histologically similar adult counterparts and standard adult criteria often cannot accurately predict their clinical behavior. The aim of the present study was to document the clinicopathologic spectrum of pediatric ACTs and to assess the utility of Wieneke scoring system in predicting clinical behavior of these tumors.
methodsThis multi-institutional study comprised of 13 cases of pediatric ACTs from January 2005 to May 2014. Clinical features and gross pathologic characteristics were obtained from records. Comprehensive analyses of microscopic features were performed. Each tumor was assessed according to criteria proposed by Wieneke et al. and was assigned to benign, intermediate for malignancy or malignant group. The standard adult Weiss criteria were also applied for comparison.
resultsThere were total 6 cases of adrenocortical adenomas and 7 cases of adrenocortical carcinomas. Most of the children (76.9%) presented with endocrine dysfunction. Lower age of presentation was significantly associated with better prognosis. Applying Wieneke criteria, there were 6 benign and 6 malignant cases and one case was assigned to intermediate for malignancy group. The clinical behavior of all the cases was consistent with Wieneke criteria categorization. Applying Weiss criteria, 3 cases with benign clinical behavior were assigned to malignant group.
conclusionOur study validates the reliability of Wieneke scoring system in predicting malignancy in pediatric ACTs. It is simple and easy to use and therefore useful in day-to-day practice.
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