ReviewInflammatory bowel diseases2015
Very early-onset inflammatory bowel disease: gaining insight through focused discovery.
Review in Inflammatory bowel diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn's Disease.Scientific reports · 2021Trial
- Identification of NovelCase reports in medicine · 2025Article
- Editorial: Exploring the interplay between clinical and non-clinical outcomes for children and adults with inflammatory bowel disease.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
- Rare variant burden analysis from exomes of three consanguineous families revealsFrontiers in medicine · 2023Article
- Bioinformatics analysis of potential key genes and pathways in neonatal necrotizing enterocolitis.BMC pediatrics · 2022Article
- Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.Journal of Crohn's & colitis · 2021Article
- IL-10 Receptor Neutralization-Induced Colitis in Mice: A Comprehensive Guide.Current protocols · 2021Article
- [Pediatric-onset Inflammatory Bowel Disease: What Are Different from Adult in the Treatment?]The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Review
- Efficient treatment of a preclinical inflammatory bowel disease model with engineered bacteria.Molecular therapy. Methods & clinical development · 2021Article
- Role of telomere shortening in anticipation of inflammatory bowel disease.World journal of gastrointestinal pharmacology and therapeutics · 2020Article
- Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.Inflammatory bowel diseases · 2020Review
- Inflammatory bowel disease: between genetics and microbiota.Molecular biology reports · 2020Review
- Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models.Intestinal research · 2020Review
- North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Evaluation and Management for Patients With Very Early-onset Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2020Article
- A 5-month-old boy with bloody stools.Paediatrics & child health · 2020Article
- Complications of enterostomy and related risk factor analysis of very early onset inflammatory bowel disease with interleukin-10 signalling deficiency: a single-centre retrospective analysis.BMC gastroenterology · 2020Article
- Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.Frontiers in immunology · 2020Article
- Gut Microbiome of Children and Adolescents With Primary Sclerosing Cholangitis in Association With Ulcerative Colitis.Frontiers in immunology · 2020Article
- Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases.World journal of gastroenterology · 2019Review
- TTC7A: Steward of Intestinal Health.Cellular and molecular gastroenterology and hepatology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pathogenesis of pediatric inflammatory bowel disease (IBD) is only partially understood. Strong evidence implicates a strong genetic component including high monozygotic twin concordance and familial disease phenotype concordance rates. Genome-wide association studies have identified associations between >160 genetic loci and the risk for developing IBD. The roles of implicated genes are largely immune-mediated, although other functions include cellular migration, oxidative stress, and carbohydrate metabolism. Additionally, growing literature describes monogenic causes of IBD that frequently present as infantile or very early-onset IBD. The interplay between IBD risk single nucleotide polymorphisms and rare genetic variants has yet to be determined. Studying patients with very early-onset IBD may elicit genetic factors that could be applied to broader populations of IBD. This review describes what is known about the genetic causes of very early-onset IBD and genetic strategies that may unravel more of the genetic causes of IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.