ArticleBehavior genetics2015
Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study.
Article in Behavior genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene-environment interplay explaining individual variation in BMI outcomes: a systematic review and meta-analysis of studies using polygenic indices.International journal of obesity (2005) · 2026Pooled it
- Neurobehavioral correlates of obesity are largely heritable.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Gene-Environment Interplay Between Residential Walkability and BMI: A Finnish Twin Study.Obesity (Silver Spring, Md.) · 2026Article
- The Association between the Obesogenic Environment and BMI Independent of Familial Factors: A Cross-Sectional Twin Study.Obesity facts · 2026Article
- Moderating the Heritability of Body Mass Index by Age and Sex With Genomic Data.Genetic epidemiology · 2026Article
- Interplay between genetic risk and built neighborhood conditions as predictor of BMI across the transition into adulthood.Obesity (Silver Spring, Md.) · 2025Article
- Epigenome-wide association study of physical activity and physiological parameters in discordant monozygotic twins.Scientific reports · 2022Article
- Two genetic analyses to elucidate causality between body mass index and personality.International journal of obesity (2005) · 2021Article
- The obesity epidemic - Nature via nurture: A narrative review of high-income countries.SAGE open medicine · 2020Review
- Cohort Profile: TWINS study of environment, lifestyle behaviours and health.International journal of epidemiology · 2019Article
- Article
- Variation in the Heritability of Child Body Mass Index by Obesogenic Home Environment.JAMA pediatrics · 2018Article
- Examination of Cross-Sectional Associations of Neighborhood Deprivation and Alcohol Outlet Density With Hazardous Drinking Using a Twin Design.Journal of studies on alcohol and drugs · 2018Article
- Obesity, diet quality, physical activity, and the built environment: the need for behavioral pathways.BMC public health · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Body mass index (BMI) has a strong genetic basis, with a heritability around 0.75, but is also influenced by numerous behavioral and environmental factors. Aspects of the built environment (e.g., environmental walkability) are hypothesized to influence obesity by directly affecting BMI, by facilitating or inhibiting behaviors such as physical activity that are related to BMI, or by suppressing genetic tendencies toward higher BMI. The present study investigated relative influences of physical activity and walkability on variance in BMI using 5079 same-sex adult twin pairs (70 % monozygotic, 65 % female). High activity and walkability levels independently suppressed genetic variance in BMI. Estimating their effects simultaneously, however, suggested that the walkability effect was mediated by activity. The suppressive effect of activity on variance in BMI was present even with a tendency for low-BMI individuals to select into environments that require higher activity levels. Overall, our results point to community- or macro-level interventions that facilitate individual-level behaviors as a plausible approach to addressing the obesity epidemic among US adults.
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