ArticleMicrobial ecology2015
Complete Genome Sequence of Bifidobacterium longum GT15: Identification and Characterization of Unique and Global Regulatory Genes.
Article in Microbial ecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Insights into toxin-antitoxin systems in the genusApplied and environmental microbiology · 2025Review
- Differential Binding of ΔFN3 Proteins ofInternational journal of molecular sciences · 2025Article
- Oxidative Stress Response of Probiotic StrainFoods (Basel, Switzerland) · 2023Article
- Article
- Study of the binding of ΔFN3.1 fragments of theMicrobiome research reports · 2023Article
- The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host's Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19.International journal of molecular sciences · 2021Review
- The Putative Antidepressant Mechanisms of Probiotic Bacteria: Relevant Genes and Proteins.Nutrients · 2021Review
- Article
- Gene Networks Underlying the Resistance ofFrontiers in immunology · 2020Article
- Mutational load in carotid body tumor.BMC medical genomics · 2019Article
- Article
- Draft Genome Sequences of Bifidobacterium angulatum GT102 and Bifidobacterium adolescentis 150: Focusing on the Genes Potentially Involved in the Gut-Brain Axis.Genome announcements · 2015Article
- Systems Biology of Microbial Exopolysaccharides Production.Frontiers in bioengineering and biotechnology · 2015Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we report the first completely annotated genome sequence of the Russia origin Bifidobacterium longum subsp. longum strain GT15. Comparative genomic analysis of this genome with other available completely annotated genome sequences of B. longum strains isolated from other countries has revealed a high degree of conservation and synteny across the entire genomes. However, it was discovered that the open reading frames to 35 genes were detected only from the B. longum GT15 genome and absent from other genomes B. longum strains (not of Russian origin). These so-called unique genes (UGs) represent a total length of 39,066 bp, with G + C content ranging from 37 to 65 %. Interestingly, certain genes were detected in other B. longum strains of Russian origin. In our analysis, we examined genes for global regulatory systems: proteins of toxin-antitoxin (TA) systems type II, serine/threonine protein kinases (STPKs) of eukaryotic type, and genes of the WhiB-like family proteins. In addition, we have made in silico analysis of all the most significant probiotic genes and considered genes involved in epigenetic regulation and genes responsible for producing various neuromediators. This genome sequence may elucidate the biology of this probiotic strain as a promising candidate for practical (pharmaceutical) applications.
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