Evidence map›Paper›PMID 25894865›Full record

Trial reportJournal of endocrinological investigation2015

A randomized-controlled, double-blind study of the impact of selenium supplementation on thyroid autoimmunity and inflammation with focus on the GPx1 genotypes.

C R de Farias, B R Cardoso, G M B de Oliveira, I C de Mello Guazzelli, R M Catarino, M C Chammas, S M F Cozzolino, M Knobel

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of endocrinological investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

C R de FariasThyroid Unit and Laboratory of Cellular and Molecular Biology (LIM-25), Division of Endocrinology and Metabolism, University of São Paulo Medical School, Hospital das Clínicas, Av. Dr. Enéas de Carvalho Aguiar, 155, 8th floor, bl 3, PAMB, São Paulo, SP, 05403-900, Brazil. cleyrocha@uol.com.br.
B R CardosoDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Av. Prof. Lineu Prestes 580, bl 14, Cidade Universitária, São Paulo, SP, 05508-000, Brazil. baritacardoso@gmail.com.
G M B de OliveiraUltrasound Unit, Department of Radiology, University of São Paulo Medical School, Hospital das Clínicas, Av Dr Enéas de Carvalho Aguiar, 255, 3rd floor, Unit 013, São Paulo, SP, 05403-900, Brazil. giovannambo@hotmail.com.
I C de Mello GuazzelliLaboratory of Cellular and Molecular Endocrinology, LIM-25, Division of Endocrinology and Metabolism, University of São Paulo Medical School, Av. Dr. Arnaldo 455, 4th floor, Units 4305/4307, São Paulo, SP, 01246-903, Brazil. belmello@usp.br.
R M CatarinoHematology and Biochemistry, Center of Pathology, Adolpho Lutz Institute, Av. Dr. Arnaldo 351, 7th floor, São Paulo, SP, 01246-000, Brazil. rmcatarino@yahoo.com.br.
M C ChammasUltrasound Unit, Department of Radiology, University of São Paulo Medical School, Hospital das Clínicas, Av. Dr. Enéas de Carvalho Aguiar, 255, 3rd floor, Unit 013, São Paulo, SP, 05403-010, Brazil. mcchammas@hotmail.com.
S M F CozzolinoDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Science, University of São Paulo, Av. Prof. Lineu Prestes 580, bl 14, Cidade Universitária, São Paulo, SP, 05508-000, Brazil. smfcozzo@usp.br.
M KnobelThyroid Unit and Laboratory of Cellular and Molecular Biology (LIM-25), Division of Endocrinology and Metabolism, University of São Paulo Medical School, Hospital das Clínicas, Av. Dr. Enéas de Carvalho Aguiar, 155, 8th floor, bl 3, PAMB, São Paulo, SP, 05403-900, Brazil. meyer.knobel@hc.fm.usp.br.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BRInstituto Adolfo Lutz · BRUniversidade Cidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the impact of selenium supplementation on serum antiTPO levels and thyroid echogenicity in patients with CAT, evaluating the response in subgroups with different GPx1 genotypes.

methodsCAT patients (n = 55) with positive antiTPO were randomized to selenomethionine (SeMet) 200 μg daily (n = 28) or placebo (n = 27) for 3 months. Assessments included GPx1 genotyping at baseline and serum levels of plasma selenium, erythrocyte GPx1 activity, antiTPO and thyroid echogenicity at baseline, and 3 and 6 months.

resultsIn the SeMet group, the increase in plasma levels of selenium and erythrocyte GPx1 activity was similar among patients with different GPx1 genotypes. In the overall cohort, patients randomized to SeMet showed a 5 % decrease in antiTPO levels at 3 months (p = non-significant) and 20 % at 6 months (p < 0.001 versus 3 months). In contrast, patients in the placebo group did not show significant changes in antiTPO levels at any time point. Subgroup analysis showed that patients with different GPx1 genotypes presented comparable responses in antiTPO levels and echogenicity index to SeMet.

conclusionsSelenium supplementation decreased serum antiTPO levels in CAT patients, with similar response among patients with different GPx1 genotypes.

Indexed as

Dietary SupplementsAdultAutoimmunityDouble-Blind MethodFemaleGenotypeGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansInflammationIodide PeroxidaseMaleMiddle AgedSelenomethionineThyroid GlandThyroiditis, AutoimmuneGlutathione PeroxidaseGlutathione Peroxidase GPX1GPX1 protein, humanIodide PeroxidaseSelenomethionineAutoimmunityGeneticGlutathione peroxidase GPx1PolymorphismSeleniumThyroid gland

Identifiers

PMID25894865
OpenAlexW2026059149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.