Evidence map›Paper›PMID 25894449›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2015

Plasma Homocysteine is a Predictive Factor for Arterial Stiffness: A Community-Based 4.8-Year Prospective Study.

Xiao-Na Wang, Ping Ye, Rui-Hua Cao, Xu Yang, Wen-Kai Xiao, Yun Zhang, Yong-Yi Bai, Hong-Mei Wu

Abstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Xiao-Na WangDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Ping YeDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Rui-Hua CaoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Xu YangDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Wen-Kai XiaoDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Yun ZhangDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Yong-Yi BaiDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Hong-Mei WuDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The authors investigated whether plasma total homocysteine (tHcy) is a predictive factor for arterial stiffness (carotid-femoral pulse wave velocity [cf-PWV] and carotid-radial PWV) in 1447 patients from a 4.8-year prospective study in Beijing, People's Republic of China. Baseline tHcy showed a significant relationship with follow-up cf-PWV (β=0.817, P=.015) in a multivariable linear regression analysis. A stepwise logistic regression model showed that baseline levels of tHcy were significantly associated with follow-up cf-PWV in the adjusted models. Furthermore, the baseline tHcy levels showed a significant association with increases in cf-PWV. There was no association between the change in tHcy and increase in PWV. The present study clearly demonstrated an association between tHcy levels and arterial stiffness, indicating that tHcy is an independent predictive factor for arterial stiffness in a community-based population.

Indexed as

Vascular StiffnessAdultAgedBiomarkersCarotid ArteriesChinaFemaleHomocysteineHumansLinear ModelsMaleMiddle AgedProspective StudiesPulse Wave AnalysisBiomarkersHomocysteine

Identifiers

PMID25894449
PMCPMC8032057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.