ArticleExperimental & applied acarology2015
An Ixodes scapularis cell line with a predominantly neuron-like phenotype.
Article in Experimental & applied acarology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Adaptation ofmSphere · 2026Article
- Genome-wide CRISPR knockout cell screening platform for the disease vector tick speciesbioRxiv : the preprint server for biology · 2026Article
- Insights into tick-pathogen interactions - a single cell RNA sequencing approach of transcriptional changes during ehrlichial infection.bioRxiv : the preprint server for biology · 2026Article
- Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission.The EMBO journal · 2026Article
- Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells.PLoS pathogens · 2025Article
- Critical roles ofInfection and immunity · 2024Article
- Croquemort elicits activation of the immune deficiency pathway in ticks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Rickettsial pathogen inhibits tick cell death through tryptophan metabolite mediated activation of p38 MAP kinase.iScience · 2023Article
- Article
- Cas9-mediated gene editing in the black-legged tick,iScience · 2022Article
- Alterations in arthropod and neuronal exosomes reduce virus transmission and replication in recipient cells.Extracellular vesicles and circulating nucleic acids · 2022Article
- Acquired tick resistance: The trail is hot.Parasite immunology · 2021Review
- Mitochondrion-Dependent Apoptosis Is Essential for Rickettsia parkeri Infection and Replication in Vector Cells.mSystems · 2021Article
- Enlisting thePathogens (Basel, Switzerland) · 2021Article
- Genetic Manipulation of Ticks: A Paradigm Shift in Tick and Tick-Borne Diseases Research.Frontiers in cellular and infection microbiology · 2021Review
- TheFrontiers in microbiology · 2021Article
- Ecological and evolutionary perspectives on tick-borne pathogen co-infections.Current research in parasitology & vector-borne diseases · 2021Review
- Interactions between Borrelia burgdorferi and ticks.Nature reviews. Microbiology · 2020Review
- The identification of tick autophagy-related genes in Ixodes scapularis responding to amino acid starvation.Ticks and tick-borne diseases · 2020Article
- Tick Cell Lines in Research on Tick Control.Frontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Ixodes scapularis embryo-derived cell line ISE6 is the most widely utilized tick-derived cell line due to its susceptibility to a wide variety of tick- and non-tick-vectored pathogens. Little is known about its tissue origin or biological background. Protein expression of ISE6 cells was compared with that of another I. scapularis-derived cell line, IDE12, and dissected tick synganglia. Results demonstrated the presence of a neuronal marker protein, type 3 β-tubulin, in all three samples, as well as other shared and unique neuronal and immune response-associated proteins. Of neuronal proteins shared between the two cell lines, ISE6 expressed several in significantly greater quantities than IDE12. Stimulation of ISE6 cells by in vivo exposure to the hemocoel environment in unfed larval and molting nymphal ticks, but not unfed nymphal ticks, resulted in the development of neuron-like morphologic characteristics in the implanted cells.
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