Pharmacodynamics: Which trails are your drugs taking?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.Pharmacological reviews · 2022
   Review
2. vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding.BMC bioinformatics · 2022
   Article
3. Link between a highMedChemComm · 2018
   Review
4. Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.British journal of pharmacology · 2017
   Article
5. Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.Journal of the American Chemical Society · 2017
   Article
6. Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies.PLoS computational biology · 2017
   Article
7. Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo.British journal of clinical pharmacology · 2016
   Review
8. Effects of target binding kinetics on in vivo drug efficacy: koff , kon and rebinding.British journal of pharmacology · 2016
   Article
9. The drug-target residence time model: a 10-year retrospective.Nature reviews. Drug discovery · 2016
   Review
10. Endless Resistance. Endless Antibiotics?MedChemComm · 2016
    Article

Corrections and comments

• Comment on
  Translating slow-binding inhibition kinetics into cellular and in vivo effects.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as