Evidence map›Paper›PMID 25893567›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2015

Biological variation, reference change value (RCV) and minimal important difference (MID) of inspiratory muscle strength (PImax) in patients with stable chronic heart failure.

Tobias Täger, Miriam Schell, Rita Cebola, Hanna Fröhlich, Andreas Dösch, Jennifer Franke, Hugo A Katus, Frank H Wians, Lutz Frankenstein

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Is there any benefit using low-intensity inspiratory and peripheral muscle training in heart failure? A randomized clinical trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2017
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tobias TägerDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Miriam SchellDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Rita CebolaDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Hanna FröhlichDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Andreas DöschDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Jennifer FrankeDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Hugo A KatusDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Frank H WiansDepartment of Pathology, Baylor University Medical Center, Dallas, TX, USA.
Lutz FrankensteinDepartment of Cardiology, Angiology, and Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Lutz.Frankenstein@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the widespread application of measurements of respiratory muscle force (PImax) in clinical trials there is no data on biological variation, reference change value (RCV), or the minimal important difference (MID) for PImax irrespective of the target cohort. We addressed this issue for patients with chronic stable heart failure. METHODS AND

resultsFrom the outpatients' clinic of the University of Heidelberg we retrospectively selected three groups of patients with stable systolic chronic heart failure (CHF). Each group had two measurements of PImax: 90 days apart in Group A (n = 25), 180 days apart in Group B (n = 93), and 365 days apart in Group C (n = 184). Stability was defined as (a) no change in NYHA class between visits and (b) absence of cardiac decompensation 3 months prior, during, and 3 months after measurements. For each group, we determined within-subject (CVI), between-subject (CVG), and total (CVT) coefficient of variation (CV), the index of individuality (II), RCV, reliability coefficient, and MID of PImax. CVT was 8.7, 7.5, and 6.9 % for groups A, B, and C, respectively. The II and RCV were 0.21, 0.20, 0.16 and 13.6, 11.6, 10.8 %, respectively. The reliability coefficient and MID were 0.83, 0.87, 0.88 and 1.44, 1.06, 1.12 kPa, respectively. Results were similar between age, gender, and aetiology subgroups.

conclusionIn patients with stable CHF, measurements of PImax are highly stable for intervals up to 1 year. The low values for II suggest that evaluation of change in PImax should be performed on an individual (per patient) basis. Individually significant change can be assumed beyond 14 % (RCV) or 1.12 kPa (MID).

Indexed as

InhalationMuscle StrengthChronic DiseaseDiaphragmFemaleGermanyHeart FailureHumansMaleMiddle AgedReference ValuesReproducibility of ResultsSensitivity and SpecificityBiological variationChronic heart failureInspiratory muscle strengthMinimal important differencePImaxReference change value

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PMID25893567

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