Evidence map›Paper›PMID 25893453›Full record

ArticleBone marrow transplantation2015

Meibography and meibomian gland measurements in ocular graft-versus-host disease.

L A Engel, S Wittig, F Bock, L Sauerbier, C Scheid, U Holtick, J-M Chemnitz, M Hallek, C Cursiefen, P Steven

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. A brief account on ocular graft versus host disease.Indian journal of ophthalmology · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Update on ocular graft-versus-host disease.Indian journal of ophthalmology · 2021
    Review
  14. Article
  15. Review
  16. Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

L A Engel1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany.
S Wittig1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany.
F Bock1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] CORIC (Cologne Ophthalmological Reading and Image Analysis Center), Department of Ophthalmology, University of Cologne, Cologne, Germany.
L Sauerbier1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] Excellence Cluster: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
C Scheid1] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany [2] Department I of Internal Medicine, University of Cologne, Cologne, Germany.
U HoltickDepartment I of Internal Medicine, University of Cologne, Cologne, Germany.
J-M ChemnitzDepartment I of Internal Medicine, University of Cologne, Cologne, Germany.
M Hallek1] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany [2] Excellence Cluster: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany [3] Department I of Internal Medicine, University of Cologne, Cologne, Germany.
C Cursiefen1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany [3] CORIC (Cologne Ophthalmological Reading and Image Analysis Center), Department of Ophthalmology, University of Cologne, Cologne, Germany.
P Steven1] Department of Ophthalmology, University of Cologne, Cologne, Germany [2] Ocular GvHD Competence Center, University of Cologne, Cologne, Germany [3] Excellence Cluster: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meibomian gland loss in ocular GvHD was described as a mechanism contributing to dry eye and severe damage to the ocular surface. Infrared images of upper eyelid meibomian glands from 86 ocular GvHD patients, from 10 patients after allogeneic stem cell transplantation (aSCT) without ocular GvHD, from 32 patients prior to aSCT and from 30 healthy controls were analyzed retrospectively and evaluated using two grading schemes. The upper meibomian gland area (uMGA) was calculated and set in relation to the total tarsal area of the lid. Results demonstrate that meibomian gland loss is significantly increased in patients with ocular GvHD as well as in patients prior to aSCT in comparison with controls (P between 0.05 and <0.001). Patients after aSCT without ocular GvHD had no significant difference in uMGA in comparison with controls. This study suggests that meibomian gland loss in GvHD patients is likely to be a multifactorial process that also occurs prior to aSCT, possibly due to underlying diseases and/or secondary to chemotherapy or irradiation. In addition, the question has to be addressed whether meibomian gland loss could serve as a predictor for the development of ocular GvHD. Overall, infrared meibography should be included in routine examination of patients undergoing aSCT and during follow-up.

Indexed as

AdultFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansMaleMeibomian GlandsMiddle AgedTransplantation ConditioningTransplantation, HomologousYoung Adult

Identifiers

PMID25893453
OpenAlexW1999660004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.