Evidence map›Paper›PMID 25893388›Full record

ArticleJournal of materials science. Materials in medicine2015

Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity.

Mehdi Shafiee Ardestani, Alireza Salehi Fordoei, Asghar Abdoli, Reza Ahangari Cohan, Golnaz Bahramali, Seyed Mehdi Sadat, Seyed Davar Siadat, Hamid Moloudian, Nasser Nassiri Koopaei, Azam Bolhasani and 4 more

Abstract read
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Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Genotoxicity of Silver Nanoparticles.Nanomaterials (Basel, Switzerland) · 2020
    Review
  9. Article
  10. Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Nano-ART and NeuroAIDS.Drug delivery and translational research · 2016
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Mehdi Shafiee ArdestaniDepartment of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Alireza Salehi Fordoei
Asghar Abdoli
Reza Ahangari Cohan
Golnaz Bahramali
Seyed Mehdi Sadat
Seyed Davar Siadat
Hamid Moloudian
Nasser Nassiri Koopaei
Azam Bolhasani
Pooneh Rahimi
Soheila Hekmat
Mehdi Davari
Mohammad Reza Aghasadeghi
Pasteur Institute of Iran · IRTehran University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV is commonly caused to a very complicated disease which has not any recognized vaccine, so designing and development of novel antiretroviral agents with specific application of nanomedicine is a globally interested research subject worldwide. In the current study, a novel structure of silver complexes with anionic linear globular dendrimer was synthesized, characterized and then assessed against HIV replication pathway in vitro as well. The results showed a very good yield of synthesis (up to 70%) for the nano-complex as well as a very potent significant (P < 0.05) antiretroviral activity with non-severe toxic effects in comparison with the Nevirapine as standard drug in positive control group. According to the present data, silver anionic linear globular dendrimers complex may have a promising future to inhibit replication of HIV viruse in clinical practice.

Indexed as

AnionsAntiviral AgentsDendrimersHIV-1Materials TestingMetal NanoparticlesParticle SizeSilverVirus ReplicationAnionsAntiviral AgentsDendrimersSilver

Identifiers

PMID25893388
OpenAlexW2064192822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.