Evidence map›Paper›PMID 25893310›Full record

ArticleCanadian respiratory journal

Diagnosis and management of asthma in preschoolers: A Canadian Thoracic Society and Canadian Paediatric Society position paper.

Francine M Ducharme, Sharon D Dell, Dhenduka Radhakrishnan, Roland M Grad, Wade T A Watson, Connie L Yang, Mitchell Zelman

Erratum issuedOpen access · goldAbstract readConsensus Statement
In one paragraph

Article in Canadian respiratory journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 141 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Prognostic utility of pre-biologic treatment correlates of childhood severe asthma exacerbation risk: Real world evidence.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  6. Article
  7. Article
  8. Association of delayed asthma diagnosis with asthma exacerbations in children.The journal of allergy and clinical immunology. Global · 2025
    Article
  9. Sex differences in sociodemographic, clinical, and laboratory variables in childhood asthma: A birth cohort study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Effect of diagnosis delay on pulmonary function in children with asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  16. Atopic asthma as a potentially significant but unrecognized risk factor for Kawasaki disease in children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022
    Article
  17. Article
  18. Tiotropium bromide as adjunct therapy in children with asthma: a clinical experience.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  19. A diagnostic codes-based algorithm improves accuracy for identification of childhood asthma in archival data sets.The Journal of asthma : official journal of the Association for the Care of Asthma · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 1 country.

Francine M Ducharme
Sharon D Dell
Dhenduka Radhakrishnan
Roland M Grad
Wade T A Watson
Connie L Yang
Mitchell Zelman
Centre Hospitalier Universitaire Sainte-Justine · CADalhousie University · CAHospital for Sick Children · CAJewish General Hospital · CAQueen Elizabeth II Health Sciences Centre · CAUniversity of British Columbia · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma often starts before six years of age. However, there remains uncertainty as to when and how a preschool-age child with symptoms suggestive of asthma can be diagnosed with this condition. This delays treatment and contributes to both short- and long-term morbidity. Members of the Canadian Thoracic Society Asthma Clinical Assembly partnered with the Canadian Paediatric Society to develop a joint working group with the mandate to develop a position paper on the diagnosis and management of asthma in preschoolers. In the absence of lung function tests, the diagnosis of asthma should be considered in children one to five years of age with frequent (≥ 8 days/month) asthma-like symptoms or recurrent (≥ 2) exacerbations (episodes with asthma-like signs). The diagnosis requires the objective document of signs or convincing parent-reported symptoms of airflow obstruction (improvement in these signs or symptoms with asthma therapy), and no clinical suspicion of an alternative diagnosis. The characteristic feature of airflow obstruction is wheezing, commonly accompanied by difficulty breathing and cough. Reversibility with asthma medications is defined as direct observation of improvement with short-acting ß2-agonists (SABA) (with or without oral corticosteroids) by a trained health care practitioner during an acute exacerbation (preferred method). However, in children with no wheezing (or other signs of airflow obstruction) on presentation, reversibility may be determined by convincing parental report of a symptomatic response to a three-month therapeutic trial of a medium dose of inhaled corticosteroids with as-needed SABA (alternative method), or as-needed SABA alone (weaker alternative method). The authors provide key messages regarding in whom to consider the diagnosis, terms to be abandoned, when to refer to an asthma specialist and the initial management strategy. Finally, dissemination plans and priority areas for research are identified.

Indexed as

Disease ManagementAlgorithmsAnti-Asthmatic AgentsAsthmaCanadaChild, PreschoolGlucocorticoidsHumansInfantReferral and ConsultationRespiratory Function TestsAnti-Asthmatic AgentsGlucocorticoids

Identifiers

PMID25893310
PMCPMC4470545
OpenAlexW1645202110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.