NEGATIVE REGULATORY EFFECTS OF PHOSPHATIDYLINOSITOL3-KINASE PATHWAY ON PHAGOCYTOSIS AND MACROPINOCYTOSIS IN BOVINE MONOCYTES.

Mais G Ammari, Autumn N Harris, John V Stokes, Richard H Bailey, Lesya M Pinchuk

Open access · greenAbstract read

In one paragraph

Article in Journal of veterinary medicine and research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 84% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Phagocytic and Bactericidal Properties of Channel Catfish Peritoneal Macrophages Exposed toFrontiers in microbiology · 2017
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mais G AmmariDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, MS 39762, USA.

Autumn N HarrisSchool of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ 85721, USA.

John V StokesDepartment of Small Animal Internal Medicine, University of Florida, Gainesville, FL 32611, USA.

Richard H BaileyDepartment of Pathobiology and Population Medicine, Mississippi State, MS 39762, USA.

Lesya M Pinchuk

Mississippi State University · USUniversity of Arizona · US

Funding

Summer Research Experience for Veterinary StudentsT35OD010432 · OD · MISSISSIPPI STATE UNIVERSITY · PI Barbara Lee-Faubert Kaplan, Temesgen Samuel · 2012 to 2026

$1.3M

NIH HHS T35 OD010432

6 · The paper itself

Abstract

Recent studies have shown that monocytes and macrophages not only present antigens to effector T cells and stimulate and shape T cell-mediated immune responses, but they also prime naïve T cells, thus initiating adaptive immune responses. Phosphatidylinositol 3-kinase functions at an early phase of toll-like receptor signaling pathways, modulates the magnitude of the primary immune responses, and is involved in the reorganization of the actin cytoskeleton during macropinocytic and phagocytic antigen uptakes, important early steps in triggering adaptive immune responses. We assessed by flow cytometry the endocytic capacities of bovine monocytes by using endocytic tracers and

Indexed as

Antigen UptakeMacropinocytosisMonocytesPhagocytosisPhosphatidylinositol 3-Kinase PathwayReceptor-Mediated EndocytosisWortmannin

Identifiers

PMID25893219

PMCPMC4399709

OpenAlexW2188511885

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.