Evidence map›Paper›PMID 25893216›Full record

ArticleeNeuro2014

Altered Brain Structure and Function Correlate with Disease Severity and Pain Catastrophizing in Migraine Patients.

Catherine S Hubbard, Shariq A Khan, Michael L Keaser, Vani A Mathur, Madhav Goyal, David A Seminowicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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  7. Treatment effects on pain catastrophizing and cutaneous allodynia symptoms in women with migraine and overweight/obesity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catherine S HubbardDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland 21201.
Shariq A KhanDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland 21201.
Michael L KeaserDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland 21201.
Vani A MathurDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland 21201.
Madhav GoyalDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland 21218.
David A SeminowiczDepartment of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland 21201.
University of Maryland, Baltimore · USJohns Hopkins University · US

Funding

Institute for Clinical and Translational Research (KL2)KL2RR025006 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$12.9M
MRI outcomes of mindfulness meditation for migraineR01AT007176 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI SEMINOWICZ, DAVID · 2013 to 2017
$3.5M
NCCIH NIH HHS R01 AT007176NCRR NIH HHS KL2 RR025006
6 · The paper itself

Abstract

To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- and surface-based morphometry along with resting-state functional connectivity to determine whether areas showing structural alterations in patients also showed abnormal functional connectivity. Additionally, we wanted to assess whether these structural and functional changes were associated with group differences in pain catastrophizing and migraine-related disease variables in patients. We acquired T1-weighted anatomical and functional magnetic resonance imaging scans during rest in human subjects with a diagnosis of migraine and healthy controls. Structural analyses revealed greater left hippocampal gray matter volume and reduced cortical thickness in the left anterior midcingulate in patients compared with controls. We also observed negative associations between pain catastrophizing and migraine disease variables and gray matter in areas implicated in processing the sensory, affective, and cognitive aspects of pain in patients. Functional connectivity analyses showed that migraine patients displayed disrupted connectivity between default mode, salience, cognitive, visuospatial, and sensorimotor networks, which was associated with group differences in pain catastrophizing and migraine-related disease variables in patients. Together, our findings show widespread morphological and functional brain abnormalities in migraineurs in affective, cognitive, visual, and pain-related brain areas, which are associated with increased pain catastrophizing, disease chronicity, and severity of symptoms, suggesting that these structural and functional changes may be a consequence of repeated, long-term nociceptive signaling leading to increased pain sensitivity, mood disturbances, and maladaptive coping strategies to deal with unrelenting pain.

Indexed as

chronic paingray matterheadacheintrinsic connectivityneuroimagingresting-state networks

Identifiers

PMID25893216
PMCPMC4399775
OpenAlexW2142885260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.