Evidence map›Paper›PMID 25893203›Full record

ArticleAnnual review of virology2014

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Vyas Ramanan, Margaret A Scull, Timothy P Sheahan, Charles M Rice, Sangeeta N Bhatia

Abstract read
In one paragraph

Article in Annual review of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Hepatitis E virus: advances and challenges.Nature reviews. Gastroenterology & hepatology · 2018
    Review
  5. Engineered Livers for Infectious Diseases.Cellular and molecular gastroenterology and hepatology · 2018
    Review
  6. Article
  7. From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling.Toxicology in vitro : an international journal published in association with BIBRA · 2017
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vyas Ramanan *Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Cambridge, Massachusetts 02139.
Margaret A Scull *Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
Timothy P SheahanCenter for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
Charles M RiceCenter for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065.
Sangeeta N BhatiaHarvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Cambridge, Massachusetts 02139.

Funding

Modeling human hepatotropic infections in complex tissue organoidsR01DK085713 · NIDDK · ROCKEFELLER UNIVERSITY · PI BHATIA, SANGEETA N., RICE, CHARLES M · 2009 to 2013
$5.6M
Structure and function of the HCV RNA replicaseR01CA057973 · NCI · WASHINGTON UNIVERSITY · PI RICE, CHARLES M · 1992 to 2013
$4.7M
Identification and characterization of cellular factors involved in HCV entryR01AI072613 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2007 to 2016
$4.7M
Role of HCV p7 and NS2 in infectious virus productionR01AI075099 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2008 to 2012
$2.1M
Hepatitis C virus host interactions in micropatterened hepatocyte co-culturesF32AI084448 · NIAID · ROCKEFELLER UNIVERSITY · PI SHEAHAN, TIMOTHY PATRICK · 2009 to 2011
$151k
Characterization and Consequences of HCV Interaction with Host LipoproteinsF32AI091207 · NIAID · ROCKEFELLER UNIVERSITY · PI SCULL, MARGARET ADELE · 2010 to 2012
$146k
NCI NIH HHS R01 CA057973NIAID NIH HHS F32 AI084448NIAID NIH HHS F32 AI091207NIAID NIH HHS R01 AI072613NIAID NIH HHS R01 AI075099NIDDK NIH HHS R01 DK085713
6 · The paper itself

Abstract

New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. Standard tissue culture models lack critical emergent properties driven by cellular organization and in vivo-like function, whereas animal models suffer from limited susceptibility to relevant human viruses and make it difficult to perform detailed molecular manipulation and analysis. Tissue engineering techniques may enable virologists to create infection models that combine the facile manipulation and readouts of tissue culture with the virus-relevant complexity of animal models. Here, we review the state of the art in tissue engineering and describe how tissue engineering techniques may alleviate some common shortcomings of existing models of viral infection, with a particular emphasis on hepatotropic viruses. We then discuss possible future applications of tissue engineering to virology, including current challenges and potential solutions.

Indexed as

cell-cell interactionscomplexityhepatotropic viruseshost-pathogen interactionspatterningprimary cells

Identifiers

PMID25893203
PMCPMC4398347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.